Andrey A Parkhitko
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Explore the profile of Andrey A Parkhitko including associated specialties, affiliations and a list of published articles.
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17
Citations
376
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Recent Articles
11.
Parkhitko A, Filine E, Mohr S, Moskalev A, Perrimon N
Ageing Res Rev
. 2020 Oct;
64:101188.
PMID: 33031925
Metabolism plays a significant role in the regulation of aging at different levels, and metabolic reprogramming represents a major driving force in aging. Metabolic reprogramming leads to impaired organismal fitness,...
12.
Parkhitko A, Jouandin P, Mohr S, Perrimon N
Aging Cell
. 2019 Aug;
18(6):e13034.
PMID: 31460700
Methionine restriction (MetR) extends lifespan across different species and exerts beneficial effects on metabolic health and inflammatory responses. In contrast, certain cancer cells exhibit methionine auxotrophy that can be exploited...
13.
Lam H, Baglini C, Lope A, Parkhitko A, Liu H, Alesi N, et al.
Cancer Res
. 2017 May;
77(12):3255-3267.
PMID: 28512249
p62/sequestosome-1 (SQSTM1) is a multifunctional adaptor protein and autophagic substrate that accumulates in cells with hyperactive mTORC1, such as kidney cells with mutations in the tumor suppressor genes tuberous sclerosis...
14.
Parkhitko A, Binari R, Zhang N, Asara J, Demontis F, Perrimon N
Genes Dev
. 2016 Jun;
30(12):1409-22.
PMID: 27313316
Aging is a risk factor for many human pathologies and is characterized by extensive metabolic changes. Using targeted high-throughput metabolite profiling in Drosophila melanogaster at different ages, we demonstrate that...
15.
Kayyali U, Larsen C, Bashiruddin S, Lewandowski S, Trivedi C, Warburton R, et al.
Cardiovasc Pathol
. 2014 Dec;
24(2):80-93.
PMID: 25434723
Despite high expression levels, the role of Tsc1 in cardiovascular tissue is ill defined. We launched this study to examine the role of Tsc1 in cardiac physiology and pathology. Mice...
16.
Parkhitko A, Priolo C, Coloff J, Yun J, Wu J, Mizumura K, et al.
Mol Cancer Res
. 2013 Dec;
12(1):48-57.
PMID: 24296756
Unlabelled: The mammalian target of rapamycin complex 1 (mTORC1) is hyperactive in many human cancers and in tuberous sclerosis complex (TSC). Autophagy, a key mTORC1-targeted process, is a critical determinant...
17.
Yu J, Parkhitko A, Henske E
Proc Am Thorac Soc
. 2010 Feb;
7(1):48-53.
PMID: 20160148
The pace of progress in lymphangioleiomyomatosis (LAM) is remarkable. In the year 2000, TSC2 gene mutations were found in LAM cells; in 2001 the tuberous sclerosis complex (TSC) genes were...
18.
Tang W, Pavlish O, Spiegelman V, Parkhitko A, Fuchs S
J Biol Chem
. 2003 Oct;
278(49):48942-9.
PMID: 14523018
The Epstein-Barr virus latent membrane protein 1 (LMP1) is pivotal in the transforming activity of this virus. We found that the common LMP1-95-8 variant interacts with Homologue of Slimb (HOS),...