Andrew W McFadden
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Explore the profile of Andrew W McFadden including associated specialties, affiliations and a list of published articles.
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10
Citations
269
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Recent Articles
1.
Vital T, Wali A, Butler K, Xiong Y, Foster 2nd J, Marcel S, et al.
Front Oncol
. 2023 Feb;
13:1099550.
PMID: 36793594
Ewing sarcoma is a cancer of children and young adults characterized by the critical translocation-associated fusion oncoprotein EWSR1::FLI1. EWSR1::FLI1 targets characteristic genetic loci where it mediates aberrant chromatin and the...
2.
Slaughter M, Shanle E, McFadden A, Hollis E, Suttle L, Strahl B, et al.
J Biol Chem
. 2018 Jul;
293(35):13592-13603.
PMID: 29986887
Chromatin remodelers use bromodomains (BDs) to recognize histones. Polybromo 1 (PBRM1 or BAF180) is hypothesized to function as the nucleosome-recognition subunit of the PBAF chromatin-remodeling complex and is frequently mutated...
3.
Pattenden S, Simon J, Wali A, Jayakody C, Troutman J, McFadden A, et al.
Proc Natl Acad Sci U S A
. 2016 Mar;
113(11):3018-23.
PMID: 26929321
Mutations in chromatin-modifying proteins and transcription factors are commonly associated with a wide variety of cancers. Through gain- or loss-of-function, these mutations may result in characteristic alterations of accessible chromatin,...
4.
Patel M, Gomez N, McFadden A, Moats-Staats B, Wu S, Rojas A, et al.
Mol Cancer Res
. 2014 Jul;
12(11):1610-20.
PMID: 24994750
Unlabelled: Recent evidence implicates the insulin-like growth factor (IGF) pathway in development of Ewing sarcoma, a highly malignant bone and soft-tissue tumor that primarily affects children and young adults. Despite...
5.
Patel M, Simon J, Iglesia M, Wu S, McFadden A, Lieb J, et al.
Genome Res
. 2011 Nov;
22(2):259-70.
PMID: 22086061
Chromosomal translocations involving transcription factor genes have been identified in an increasingly wide range of cancers. Some translocations can create a protein "chimera" that is composed of parts from different...
6.
Davis I, McFadden A, Zhang Y, Coxon A, Burgess T, Wagner A, et al.
Cancer Res
. 2010 Jan;
70(2):639-45.
PMID: 20068147
Clear cell sarcoma (CCS), a childhood tumor of the tendons and aponeuroses, is uniformly fatal once it has metastasized because of its profound therapeutic resistance. CCS is characterized by production...
7.
Zayed M, Yuan W, Leisner T, Chalothorn D, McFadden A, Schaller M, et al.
Circ Res
. 2007 Nov;
101(11):1185-93.
PMID: 17975111
Pathological angiogenesis contributes to various ocular, malignant, and inflammatory disorders, emphasizing the need to understand this process on a molecular level. CIB1 (calcium- and integrin-binding protein), a 22-kDa EF-hand-containing protein,...
8.
Liu J, DeNofrio J, Yuan W, Wang Z, McFadden A, Parise L
Curr Top Dev Biol
. 2007 Oct;
80:311-35.
PMID: 17950378
Proper platelet function is essential for hemostasis. However, understanding platelet function is complicated by the fact that platelets are anucleate and therefore not amenable to direct genetic manipulations. To study...
9.
Yuan W, Leisner T, McFadden A, Clark S, Hiller S, Maeda N, et al.
Mol Cell Biol
. 2006 Sep;
26(22):8507-14.
PMID: 16982698
CIB1 is a 22-kDa calcium binding, regulatory protein with approximately 50% homology to calmodulin and calcineurin B. CIB1 is widely expressed and binds to a number of effectors, such as...
10.
Yuan W, Leisner T, McFadden A, Wang Z, Larson M, Clark S, et al.
J Cell Biol
. 2006 Jan;
172(2):169-75.
PMID: 16418530
In response to agonist stimulation, the alphaIIbbeta3 integrin on platelets is converted to an active conformation that binds fibrinogen and mediates platelet aggregation. This process contributes to both normal hemostasis...