Andrew Tsourkas
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Explore the profile of Andrew Tsourkas including associated specialties, affiliations and a list of published articles.
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140
Citations
3418
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Recent Articles
21.
Altshuler P, Schiazza A, Luo L, Helmers M, Chhay B, Han J, et al.
Adv Ther (Weinh)
. 2021 Jun;
4(6).
PMID: 34179348
Early revascularization is critical to reduce morbidity after myocardial infarction, although reperfusion incites additional oxidative injury. Superoxide dismutase (SOD) is an antioxidant that scavenges reactive oxygen species (ROS) but has...
22.
Yu W, Gillespie K, Chhay B, Svensson A, Nygren P, Blair I, et al.
Bioconjug Chem
. 2021 May;
32(6):1058-1066.
PMID: 34029057
Antibody-drug conjugates (ADCs) have demonstrated great therapeutic potential due to their ability to target the delivery of potent cytotoxins. However, the heterogeneous nature of conventional drug conjugation strategies can affect...
23.
Wei Y, Yan L, Luo L, Gui T, Jang B, Amirshaghaghi A, et al.
Sci Adv
. 2021 Apr;
7(15).
PMID: 33827816
Treating osteoarthritis (OA) remains a major clinical challenge. Despite recent advances in drug discovery and development, no disease-modifying drug for knee OA has emerged with any notable clinical success, in...
24.
Wei Y, Luo L, Gui T, Yu F, Yan L, Yao L, et al.
Sci Transl Med
. 2021 Jan;
13(576).
PMID: 33441426
Osteoarthritis (OA) is a widespread joint disease for which there are no disease-modifying treatments. Previously, we found that mice with cartilage-specific epidermal growth factor receptor (EGFR) deficiency developed accelerated knee...
25.
Teng C, Amirshaghaghi A, Cho S, Cai S, De Ravin E, Singh Y, et al.
J Neurooncol
. 2020 Sep;
149(2):243-252.
PMID: 32914293
Introduction: Glioblastoma multiforme (GBM) is the most common primary intracranial malignancy; survival can be improved by maximizing the extent-of-resection. Methods: A near-infrared fluorophore (Indocyanine-Green, ICG) was combined with a photosensitizer...
26.
Moon B, Iyer S, Hwuang E, Solomon M, Hall A, Kumar R, et al.
Nat Commun
. 2020 Jul;
11(1):3273.
PMID: 32601301
Restoration of coronary blood flow after a heart attack can cause reperfusion injury potentially leading to impaired cardiac function, adverse tissue remodeling and heart failure. Iron is an essential biometal...
27.
Cho S, Sheikh S, Teng C, Georges J, Yang A, De Ravin E, et al.
Mol Imaging Biol
. 2020 Jun;
22(5):1266-1279.
PMID: 32514886
Purpose: Fluorescence-guided-surgery offers intraoperative visualization of neoplastic tissue. Delta-aminolevulinic acid (5-ALA), which targets enzymatic abnormality in neoplastic cells, is the only approved agent for fluorescence-guided neurosurgery. More recently, we described...
28.
Kartha S, Yan L, Ita M, Amirshaghaghi A, Luo L, Wei Y, et al.
ACS Nano
. 2020 Jun;
14(7):8103-8115.
PMID: 32484651
Treating persistent neuropathic pain remains a major clinical challenge. Current conventional treatment approaches carry a substantial risk of toxicity and provide only transient pain relief. In this work, we show...
29.
Luo L, Yan L, Amirshaghaghi A, Wei Y, You T, Singhal S, et al.
ACS Appl Bio Mater
. 2020 May;
3(4):2344-2349.
PMID: 32455339
Recently, near-infrared (NIR) fluorescent dyes such as indocyanine green (ICG) have received tremendous interest as contrast agents for use in fluorescence-guided, intraoperative cancer resection surgery. However, despite showing great promise,...
30.
Higbee-Dempsey E, Amirshaghaghi A, Case M, Bouche M, Kim J, Cormode D, et al.
J Am Chem Soc
. 2020 Apr;
142(17):7783-7794.
PMID: 32271558
Gold is a highly useful nanomaterial for many clinical applications, but its poor biodegradability can impair long-term physiological clearance. Large gold nanoparticles (∼10-200 nm), such as those required for long...