Andrew Tsourkas
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Explore the profile of Andrew Tsourkas including associated specialties, affiliations and a list of published articles.
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Articles
140
Citations
3418
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Recent Articles
11.
Amirshaghaghi A, Chang W, Chhay B, Bartolomeu A, Clapper M, Cheng Z, et al.
ACS Appl Mater Interfaces
. 2023 Jul;
15(28):33373-33381.
PMID: 37395349
The current standard of care for colon cancer surveillance relies heavily on white light endoscopy (WLE). However, dysplastic lesions that are not visible to the naked eye are often missed...
12.
Haley R, Chan A, Billingsley M, Gong N, Padilla M, Kim E, et al.
ACS Appl Mater Interfaces
. 2023 Apr;
15(18):21877-21892.
PMID: 37115558
Mutated RAS proteins are potent oncogenic drivers and have long been considered "undruggable". While RAS-targeting therapies have recently shown promise, there remains a clinical need for RAS inhibitors with more...
13.
Niu J, Hagen J, Yu F, Kalyuzhny A, Tsourkas A
Methods Mol Biol
. 2022 Dec;
2593:113-126.
PMID: 36513927
Spatial proteomics has recently garnered significant interest, as it offers to provide unprecedented insight into biological processes in both health and disease, by connecting protein expression patterns from the subcellular...
14.
Gui T, Wei Y, Luo L, Li J, Zhong L, Yao L, et al.
J Bone Miner Res
. 2022 Sep;
37(12):2498-2511.
PMID: 36178273
Posttraumatic osteoarthritis (PTOA) results in joint pain, loss of joint function, and impaired quality of daily life in patients with limited treatment options. We previously demonstrated that epidermal growth factor...
15.
Farokhirad S, Kutti Kandy S, Tsourkas A, Ayyaswamy P, Eckmann D, Radhakrishnan R
Adv Mater Interfaces
. 2022 Jul;
8(23).
PMID: 35782961
How nanoparticle (NP) mechanical properties impact multivalent ligand-receptor-mediated binding to cell surfaces, the avidity, propensity for internalization, and effects due to crowding remains unknown or unquantified. Through computational analyses, the...
16.
Zappala F, Higbee-Dempsey E, Jang B, Miller J, Yan L, Minutolo N, et al.
Sci Adv
. 2022 May;
8(18):eabn4613.
PMID: 35522741
Extensive antibody engineering and cloning is typically required to generate new bispecific antibodies. Made-to-order genes, advanced expression systems, and high-efficiency cloning can simplify and accelerate this process, but it still...
17.
Higbee-Dempsey E, Amirshaghaghi A, Case M, Miller J, Busch T, Tsourkas A
Adv Ther (Weinh)
. 2022 May;
2(9).
PMID: 35494480
Traditional oncology treatment modalities are often associated with a poor therapeutic index. This has driven the development of new targeted treatment modalities, including several based on the conversion of optical...
18.
Gui T, Luo L, Chhay B, Zhong L, Wei Y, Yao L, et al.
Biomaterials
. 2022 Mar;
283:121437.
PMID: 35247635
Oxidative stress and the reactive oxygen species (ROS) have important roles in osteoarthritis (OA) development and progression. Scavenging ROS by exogenous antioxidant enzymes could be a promising approach for OA...
19.
Chan A, Wang H, Haley R, Song C, Gonzalez-Martinez D, Bugaj L, et al.
Mol Pharm
. 2022 Feb;
19(4):1104-1116.
PMID: 35225618
The ability to deliver small protein scaffolds intracellularly could enable the targeting and inhibition of many therapeutic targets that are not currently amenable to inhibition with small-molecule drugs. Here, we...
20.
Mei L, Zappala F, Tsourkas A
Bioconjug Chem
. 2021 Dec;
33(1):134-141.
PMID: 34894663
Bispecific antibodies (BsAb) refer to a class of biomacromolecules that are capable of binding two antigens or epitopes simultaneously. This can elicit unique biological effects that cannot be achieved with...