Andrew Savinov
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Explore the profile of Andrew Savinov including associated specialties, affiliations and a list of published articles.
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10
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88
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Recent Articles
1.
Savinov A, Swanson S, Keating A, Li G
Proc Natl Acad Sci U S A
. 2025 Feb;
122(6):e2322412122.
PMID: 39899719
Peptides can bind to specific sites on larger proteins and thereby function as inhibitors and regulatory elements. Peptide fragments of larger proteins are particularly attractive for achieving these functions due...
2.
Savinov A
Trends Biochem Sci
. 2024 Jul;
49(10):841-842.
PMID: 39048479
Recent work from Nguyen et al. unveils massively parallel measurements of epistatic interactions between two enzymes, dihydrofolate reductase and thymidylate synthase, in their natural cellular context. Almost 3000 mutations of...
3.
Savinov A, Swanson S, Keating A, Li G
bioRxiv
. 2024 Jan;
PMID: 38187731
Peptides can bind to specific sites on larger proteins and thereby function as inhibitors and regulatory elements. Peptide fragments of larger proteins are particularly attractive for achieving these functions due...
4.
Savinov A, Fernandez A, Fields S
Proc Natl Acad Sci U S A
. 2022 Jun;
119(26):e2200124119.
PMID: 35749361
Massively parallel measurements of dominant-negative inhibition by protein fragments have been used to map protein interaction sites and discover peptide inhibitors. However, the underlying principles governing fragment-based inhibition have thus...
5.
Savinov A, Brandsen B, Angell B, Cuperus J, Fields S
Genome Biol
. 2021 Oct;
22(1):293.
PMID: 34663436
Background: The 3' untranslated region (UTR) plays critical roles in determining the level of gene expression through effects on activities such as mRNA stability and translation. Functional elements within this...
6.
Savinov A, Roth F
Cell Syst
. 2021 Jul;
12(7):691-693.
PMID: 34293323
Systematic, high-throughput screening for "dominant-negative" protein fragments is an emerging method for mapping functional regions of the parental protein in vivo. In this issue of Cell Systems, Ford et al....
7.
Andreasson J, Savinov A, Block S, Greenleaf W
Nat Commun
. 2020 Apr;
11(1):1663.
PMID: 32245964
Massively parallel, quantitative measurements of biomolecular activity across sequence space can greatly expand our understanding of RNA sequence-function relationships. We report the development of an RNA-array assay to perform such...
8.
Garner R, Skariah G, Hadjitheodorou A, Belliveau N, Savinov A, Footer M, et al.
Cytoskeleton (Hoboken)
. 2020 Feb;
77(5-6):181-196.
PMID: 32072765
Observations of actin dynamics in living cells using fluorescence microscopy have been foundational in the exploration of the mechanisms underlying cell migration. We used CRISPR/Cas9 gene editing to generate neutrophil-like...
9.
Savinov A, Block S
Proc Natl Acad Sci U S A
. 2018 Nov;
115(47):11976-11981.
PMID: 30397151
Riboswitches modulate gene expression in response to small-molecule ligands. Switching is generally thought to occur via the stabilization of a specific RNA structure conferred by binding the cognate ligand. However,...
10.
Savinov A, Perez C, Block S
Biochim Biophys Acta
. 2014 Apr;
1839(10):1030-1045.
PMID: 24727093
The folding dynamics of riboswitches are central to their ability to modulate gene expression in response to environmental cues. In most cases, a structural competition between the formation of a...