Andrew N Lane
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Explore the profile of Andrew N Lane including associated specialties, affiliations and a list of published articles.
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134
Citations
7986
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Recent Articles
1.
Lin P, Lane A, W-M Fan T
Methods Mol Biol
. 2024 Oct;
2855:457-504.
PMID: 39354323
NMR is widely used for metabolite profiling (metabolomics, metabonomics) particularly of various readily obtainable biofluids such as plasma and urine. It is especially valuable for stable isotope tracer studies to...
2.
Vicente-Munoz S, Davis J, Lane A, Lane A, Waltz S, Wells S
Front Oncol
. 2024 Oct;
14:1382986.
PMID: 39351361
Recurrent and metastatic breast cancer is frequently treatment resistant. A wealth of evidence suggests that reprogrammed lipid metabolism supports cancer recurrence. Overexpression of the RON and DEK oncoproteins in breast...
3.
Kinslow C, Ll M, Cai Y, Yan J, Lorkiewicz P, Al-Attar A, et al.
Metabolomics
. 2024 Jul;
20(4):87.
PMID: 39068202
Introduction: Stable isotope tracers have been increasingly used in preclinical cancer model systems, including cell culture and mouse xenografts, to probe the altered metabolism of a variety of cancers, such...
4.
Lane A, Higashi R, W-M Fan T
Metabolites
. 2024 Jul;
14(7).
PMID: 39057706
Stable isotope-resolved metabolomics comprises a critical set of technologies that can be applied to a wide variety of systems, from isolated cells to whole organisms, to define metabolic pathway usage...
5.
W-M Fan T, Higashi R, Lane A
Cold Spring Harb Perspect Med
. 2024 Jul;
PMID: 39009444
Stable isotope-resolved metabolomics delineates reprogrammed intersecting metabolic networks in human cancers. Knowledge gained from in vivo patient studies provides the "benchmark" for cancer models to recapitulate. It is particularly difficult...
6.
Lin P, Sledziona J, Akkaya-Colak K, Mihaylova M, Lane A
Anal Chim Acta
. 2024 Apr;
1303:342511.
PMID: 38609261
Background: Mammalian cells both import exogenous fatty acids and synthesize them de novo. Palmitate, the end product of fatty acid synthase (FASN) is a substrate for stearoyl-CoA desaturases (Δ-9 desaturases)...
7.
Daneshmandi S, Choi J, Yan Q, MacDonald C, Pandey M, Goruganthu M, et al.
Nat Commun
. 2024 Mar;
15(1):2803.
PMID: 38555305
Myeloid derived suppressor cells (MDSCs) are key regulators of immune responses and correlate with poor outcomes in hematologic malignancies. Here, we identify that MDSC mitochondrial fitness controls the efficacy of...
8.
Holling G, Chavel C, Sharda A, Lieberman M, James C, Lightman S, et al.
Cell Mol Immunol
. 2024 Jan;
21(3):260-274.
PMID: 38233562
Metabolic flexibility has emerged as a critical determinant of CD8+ T-cell antitumor activity, yet the mechanisms driving the metabolic flexibility of T cells have not been determined. In this study,...
9.
Zhang X, Su Y, Lane A, Stromberg A, Fan T, Wang C
BMC Bioinformatics
. 2024 Jan;
25(1):14.
PMID: 38200423
No abstract available.
10.
Wu H, Kren B, Lane A, Cassel T, Higashi R, Fan T, et al.
J Biol Chem
. 2023 Dec;
299(12):105407.
PMID: 38152849
Cell proliferation requires metabolic reprogramming to accommodate biosynthesis of new cell components, and similar alterations occur in cancer cells. However, the mechanisms linking the cell cycle machinery to metabolism are...