Andrew Ming-Lum
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Explore the profile of Andrew Ming-Lum including associated specialties, affiliations and a list of published articles.
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7
Citations
184
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Recent Articles
1.
Chamberlain T, Cheung S, Yoon J, Ming-Lum A, Gardill B, Shakibakho S, et al.
iScience
. 2020 Aug;
23(8):101433.
PMID: 32823063
The anti-inflammatory actions of interleukin-10 (IL10) are thought to be mediated primarily by the STAT3 transcription factor, but pro-inflammatory cytokines such as interleukin-6 (IL6) also act through STAT3. We now...
2.
Cheung S, So E, Chang D, Ming-Lum A, Mui A
PLoS One
. 2013 Aug;
8(8):e71336.
PMID: 23951138
The anti-inflammatory cytokine interleukin-10 (IL-10) is essential for attenuating the inflammatory response, which includes reducing the expression of pro-inflammatory microRNA-155 (miR-155) in lipopolysaccharide (LPS) activated macrophages. miR-155 enhances the expression...
3.
Chan C, Ming-Lum A, Golds G, Lee S, Anderson R, Mui A
J Biol Chem
. 2012 Sep;
287(45):38020-7.
PMID: 22955274
Production of the proinflammatory cytokine TNFα by activated macrophages is an important component of host defense. However, TNFα production must be tightly controlled to avoid pathological consequences. The anti-inflammatory cytokine...
4.
Ming-Lum A, Shojania S, So E, McCarrell E, Shaw E, Vu D, et al.
FASEB J
. 2012 Jun;
26(8):3163-77.
PMID: 22651931
SH2 domain-containing inositol-5'-phosphatase-1 (SHIP1) inhibits inflammation by hydrolyzing phosphoinositide-3'-kinase generated membrane phosphatidylinositol-3,4,5-trisphosphate (PIP(3)). Bioinformatic analysis of SHIP1 from multiple species revealed a pleckstrin homololgy-related (PH-R) domain, which we hypothesize mediates...
5.
Ong C, Ming-Lum A, Nodwell M, Ghanipour A, Yang L, Williams D, et al.
Blood
. 2007 May;
110(6):1942-9.
PMID: 17502453
Because phosphoinositide 3-kinase (PI3K) plays a central role in cellular activation, proliferation, and survival, pharmacologic inhibitors targeting components of the PI3K pathway are actively being developed as therapeutics for the...
6.
Wei S, Ming-Lum A, Liu Y, Wallach D, Ong C, Chung S, et al.
J Interferon Cytokine Res
. 2006 May;
26(5):281-90.
PMID: 16689656
The cytokine interleukin-10 (IL-10) is an important regulator of immune cell function, proliferation, and survival. The IL-10 receptor (IL-10R) consists of two subunits, IL-10R1 and IL-10R2, both belonging to the...
7.
Qasimi P, Ming-Lum A, Ghanipour A, Ong C, Cox M, Ihle J, et al.
J Biol Chem
. 2005 Dec;
281(10):6316-24.
PMID: 16352613
The cytokine interleukin-10 (IL-10) potently inhibits macrophage function through activation of the transcription factor STAT3. The expression of SOCS3 (suppressor of cytokine signaling-3) has been shown to be induced by...