Andrew F Siegel
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Explore the profile of Andrew F Siegel including associated specialties, affiliations and a list of published articles.
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12
Citations
927
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Recent Articles
1.
Taylor R, Siegel A, Galitski T
Genome Biol
. 2007 Aug;
8(8):R160.
PMID: 17683534
Different modes of genetic interaction indicate different functional relationships between genes. The extraction of biological information from dense multi-mode genetic-interaction networks demands appropriate statistical and computational methods. We developed such...
2.
DallEra M, True L, Siegel A, Porter M, Sherertz T, Liu A
BMC Urol
. 2007 Mar;
7:3.
PMID: 17335564
Background: CD10 is a transmembrane metallo-endopeptidase that cleaves and inactivates a variety of peptide growth factors. Loss of CD10 expression is a common, early event in human prostate cancer; however,...
3.
Roach J, Deutsch K, Li S, Siegel A, Bekris L, Einhaus D, et al.
Am J Hum Genet
. 2006 Sep;
79(4):614-27.
PMID: 16960798
We mapped the genetic influences for type 1 diabetes (T1D), using 2,360 single-nucleotide polymorphism (SNP) markers in the 4.4-Mb human major histocompatibility complex (MHC) locus and the adjacent 493 kb...
4.
Thorsson V, Hornquist M, Siegel A, Hood L
Stat Appl Genet Mol Biol
. 2006 May;
4:Article28.
PMID: 16646846
We examine the application of statistical model selection methods to reverse-engineering the control of galactose utilization in yeast from DNA microarray experiment data. In these experiments, relationships among gene expression...
5.
Glusman G, Qin S, El-Gewely M, Siegel A, Roach J, Hood L, et al.
PLoS Comput Biol
. 2006 Mar;
2(3):e18.
PMID: 16543943
The identification and characterization of the complete ensemble of genes is a main goal of deciphering the digital information stored in the human genome. Many algorithms for computational gene prediction...
6.
Dilworth D, Tackett A, Rogers R, Yi E, Christmas R, Smith J, et al.
J Cell Biol
. 2005 Dec;
171(6):955-65.
PMID: 16365162
Nuclear pore complexes (NPCs) govern macromolecular transport between the nucleus and cytoplasm and serve as key positional markers within the nucleus. Several protein components of yeast NPCs have been implicated...
7.
Hwang D, Rust A, Ramsey S, Smith J, Leslie D, Weston A, et al.
Proc Natl Acad Sci U S A
. 2005 Nov;
102(48):17296-301.
PMID: 16301537
Different experimental technologies measure different aspects of a system and to differing depth and breadth. High-throughput assays have inherently high false-positive and false-negative rates. Moreover, each technology includes systematic biases...
8.
Hwang D, Smith J, Leslie D, Weston A, Rust A, Ramsey S, et al.
Proc Natl Acad Sci U S A
. 2005 Nov;
102(48):17302-7.
PMID: 16301536
The integration of data from multiple global assays is essential to understanding dynamic spatiotemporal interactions within cells. In a companion paper, we reported a data integration methodology, designated Pointillist, that...
9.
Prinz S, Avila-Campillo I, Aldridge C, Srinivasan A, Dimitrov K, Siegel A, et al.
Genome Res
. 2004 Mar;
14(3):380-90.
PMID: 14993204
On solid growth media with limiting nitrogen source, diploid budding-yeast cells differentiate from the yeast form to a filamentous, adhesive, and invasive form. Genomic profiles of mRNA levels in Saccharomyces...
10.
Kolker E, Purvine S, Galperin M, Stolyar S, Goodlett D, Nesvizhskii A, et al.
J Bacteriol
. 2003 Jul;
185(15):4593-602.
PMID: 12867470
The proteome of Haemophilus influenzae strain Rd KW20 was analyzed by liquid chromatography (LC) coupled with ion trap tandem mass spectrometry (MS/MS). This approach does not require a gel electrophoresis...