Andrew D Mesecar
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Explore the profile of Andrew D Mesecar including associated specialties, affiliations and a list of published articles.
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128
Citations
6329
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Recent Articles
1.
Riva L, Yuan S, Yin X, Martin-Sancho L, Matsunaga N, Pache L, et al.
Nature
. 2024 Jun;
631(8019):E3.
PMID: 38890463
No abstract available.
2.
Ghosh A, Yadav M, Iddum S, Ghazi S, Lendy E, Jayashankar U, et al.
Eur J Med Chem
. 2024 Feb;
267:116132.
PMID: 38335815
We report the synthesis, biological evaluation, and X-ray structural studies of a series of SARS-CoV-2 Mpro inhibitors based upon the X-ray crystal structure of nirmatrelvir, an FDA approved drug that...
3.
Jesudason C, Mason E, Chu S, Oblak A, Javens-Wolfe J, Moussaif M, et al.
Alzheimers Dement (N Y)
. 2023 Nov;
9(4):e12429.
PMID: 38023622
Introduction: The risk of developing Alzheimer's disease is associated with genes involved in microglial function. Inositol polyphosphate-5-phosphatase (), which encodes Src homology 2 (SH2) domain-containing inositol polyphosphate 5-phosphatase 1 (SHIP1),...
4.
Ghosh A, Shahabi D, Imhoff M, Kovela S, Sharma A, Hattori S, et al.
Bioorg Med Chem Lett
. 2023 Sep;
96:129489.
PMID: 37770002
We report here the synthesis and biological evaluation of a series of small molecule SARS-CoV-2 PLpro inhibitors. We compared the activity of selected compounds in both SARS-CoV-1 and SARS-CoV-2 PLpro...
5.
Tsai A, Dong C, Lin P, Oblak A, Di Prisco G, Wang N, et al.
Immunity
. 2023 Sep;
56(9):2121-2136.e6.
PMID: 37659412
Genetic association studies have demonstrated the critical involvement of the microglial immune response in Alzheimer's disease (AD) pathogenesis. Phospholipase C-gamma-2 (PLCG2) is selectively expressed by microglia and functions in many...
6.
Bose S, Steussy C, Lopez-Perez D, Schmidt T, Kulathunga S, Seleem M, et al.
Commun Biol
. 2023 Apr;
6(1):360.
PMID: 37012403
HMG-CoA reductase (HMGR), a rate-limiting enzyme of the mevalonate pathway in Gram-positive pathogenic bacteria, is an attractive target for development of novel antibiotics. In this study, we report the crystal...
7.
Kulathunga S, Morato N, Zhou Q, Cooks R, Mesecar A
ChemMedChem
. 2022 Jan;
17(9):e202200043.
PMID: 35080134
The sulfotransferase (SULT) 2B1b, which catalyzes the sulfonation of 3β-hydroxysteroids, has been identified as a potential target for prostate cancer treatment. However, a major limitation for SULT2B1b-targeted drug discovery is...
8.
Boras B, Jones R, Anson B, Arenson D, Aschenbrenner L, Bakowski M, et al.
Nat Commun
. 2021 Oct;
12(1):6055.
PMID: 34663813
COVID-19 caused by the SARS-CoV-2 virus has become a global pandemic. 3CL protease is a virally encoded protein that is essential across a broad spectrum of coronaviruses with no close...
9.
Ghosh A, Shahabi D, Yadav M, Kovela S, Anson B, Lendy E, et al.
Molecules
. 2021 Oct;
26(19).
PMID: 34641337
We report the design and synthesis of a series of new 5-chloropyridinyl esters of salicylic acid, ibuprofen, indomethacin, and related aromatic carboxylic acids for evaluation against SARS-CoV-2 3CL protease enzyme....
10.
Ghosh A, Raghavaiah J, Shahabi D, Yadav M, Anson B, Lendy E, et al.
J Med Chem
. 2021 Sep;
64(19):14702-14714.
PMID: 34528437
Here, we report the synthesis, structure-activity relationship studies, enzyme inhibition, antiviral activity, and X-ray crystallographic studies of 5-chloropyridinyl indole carboxylate derivatives as a potent class of SARS-CoV-2 chymotrypsin-like protease inhibitors....