Andrew D Hamilton
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Explore the profile of Andrew D Hamilton including associated specialties, affiliations and a list of published articles.
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177
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3880
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Recent Articles
11.
Kazi A, Xiang S, Yang H, Chen L, Kennedy P, Ayaz M, et al.
Clin Cancer Res
. 2019 Jun;
25(19):5984-5996.
PMID: 31227505
Purpose: Mutant KRAS is a major driver of pancreatic oncogenesis and therapy resistance, yet KRAS inhibitors are lacking in the clinic. KRAS requires farnesylation for membrane localization and cancer-causing activity...
12.
Maity D, Kumar S, Curreli F, Debnath A, Hamilton A
Chemistry
. 2019 Mar;
25(30):7265-7269.
PMID: 30825250
An oligopyridylamide-based foldamer approach has been employed to target HIV TAR RNA-TAT assembly as a model system to study RNA-protein interactions. The oligopyridylamide scaffold adopts a constrained conformation which presents...
13.
Meisel J, Hu C, Hamilton A
Org Lett
. 2018 Jun;
20(13):3879-3882.
PMID: 29897248
The design and characterization of a proteomimetic foldamer that displays lateral flexibility endowed by intramolecular bifurcated hydrogen bonds is reported. The MAMBA scaffold, derived from meta-aminomethylbenzoic acid, adopts a serpentine...
14.
Choi K, Hamilton A
Angew Chem Int Ed Engl
. 2018 May;
40(20):3912-3915.
PMID: 29712141
A macrocycle containing an aminocoumarin fluorophore showed two different fluorescence emission bands on binding with certain anions. Proton transfer from the fluorophore excited state occurred depending on the basicity of...
15.
Lee C, Yu J, Kumar S, Jin Y, LeRoy G, Bhanu N, et al.
Mol Cell
. 2018 Apr;
70(3):422-434.e6.
PMID: 29681499
PRC2 is a therapeutic target for several types of cancers currently undergoing clinical trials. Its activity is regulated by a positive feedback loop whereby its terminal enzymatic product, H3K27me3, is...
16.
Kumar S, Henning-Knechtel A, Magzoub M, Hamilton A
J Am Chem Soc
. 2018 Apr;
140(21):6562-6574.
PMID: 29648815
The prevailing hypothesis stipulates that the preamyloid oligomers of Aβ are the main culprits associated with the onset and progression of Alzheimer's disease (AD), which has prompted efforts to search...
17.
Kumar S, Vogel M, Hamilton A
Org Biomol Chem
. 2018 Jan;
16(5):733-741.
PMID: 29303519
A library of N-substituted oligopyrrolamides was designed to modulate the aggregation kinetics of islet amyloid polypeptide (IAPP). IAPP is a hormonal peptide, co-secreted with insulin in the pancreatic β-cells. IAPP...
18.
Luccarelli J, Jones I, Thompson S, Hamilton A
Org Biomol Chem
. 2017 Oct;
15(43):9156-9163.
PMID: 29058730
Hydrogen bonding plays an essential part in dictating the properties of natural and synthetic materials. Secondary amides are well suited to cross-strand interactions through the display of both hydrogen bond...
19.
Kumar S, Henning-Knechtel A, Chehade I, Magzoub M, Hamilton A
J Am Chem Soc
. 2017 Oct;
139(47):17098-17108.
PMID: 29058422
The conversion of the native random coil amyloid beta (Aβ) into amyloid fibers is thought to be a key event in the progression of Alzheimer's disease (AD). A significant body...
20.
Knipe P, Thompson S, Hamilton A
Chem Sci
. 2017 Jul;
6(3):1630-1639.
PMID: 28694943
Molecular switches are ubiquitous in Nature and provide the basis of many forms of transport and signalling. synthetic molecules that change conformation, and thus function, reversibly in a stimulus-dependent manner...