Andrew D Hamilton
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Explore the profile of Andrew D Hamilton including associated specialties, affiliations and a list of published articles.
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177
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Recent Articles
21.
Peacock H, Luo J, Yamashita T, Luccarelli J, Thompson S, Hamilton A
Chem Sci
. 2017 Apr;
7(10):6435-6439.
PMID: 28451100
Conformationally-constrained molecules that selectively recognise the surfaces of proteins have the potential to direct the path of protein folding. Such molecules are of therapeutic interest because the misfolding of proteins,...
22.
Kumar S, Hamilton A
J Am Chem Soc
. 2017 Mar;
139(16):5744-5755.
PMID: 28273416
A key molecular species in Alzheimer's disease (AD) is the Aβ alloform of Aβ peptide, which is dominant in the amyloid plaques deposited in the brains of AD patients. Recent...
23.
Busschaert N, Thompson S, Hamilton A
Chem Commun (Camb)
. 2016 Nov;
53(2):313-316.
PMID: 27892554
A novel oligobenzamide-based α-helix mimetic was designed and synthesised with either imine or hydrazone functionalities that serve both to pre-organise the side-chain vectors to mimic the i, i + 4...
24.
Knipe P, Thompson S, Hamilton A
Chem Commun (Camb)
. 2016 Apr;
52(39):6521-4.
PMID: 27045691
Induced conformational change provides a powerful mechanism to modulate the structure and function of molecules. Here we describe the synthesis of chiral, surface-functionalized oligomeric pyridine/imidazolidin-2-one foldamers, and interrogate their acid-mediated...
25.
Yamashita T, Knipe P, Busschaert N, Thompson S, Hamilton A
Chemistry
. 2015 Sep;
21(42):14699-702.
PMID: 26384862
A promising strategy for mediating protein-protein interactions is the use of non-peptidic mimics of secondary structural protein elements, such as the α-helix. Recent work has expanded the scope of this...
26.
Yamashita T, Knipe P, Busschaert N, Thompson S, Hamilton A
Chemistry
. 2015 Sep;
21(42):14657.
PMID: 26333029
Invited for the cover of this issue is the group of Andrew D. Hamilton and Sam Thompson at the University of Oxford (UK). The image depicts a new class of...
27.
Ross J, Knipe P, Thompson S, Hamilton A
Chemistry
. 2015 Aug;
21(39):13518-21.
PMID: 26264561
Functionalized diphenylalkynes provide a template for the presentation of protein-like surfaces composed of multistrand β-sheets. The conformational properties of three-, four-, and seven-stranded systems have been investigated in the solid-...
28.
Nevola L, Rodriguez J, Thompson S, Hamilton A
Supramol Chem
. 2015 Jun;
25(9-11):586-590.
PMID: 26052191
The α-α helix motif presents key recognition domains in protein-protein and protein-oligonucleotide binding, and is one of the most common super-secondary structures. Herein we describe the design, synthesis and structural...
29.
Kumar S, Schlamadinger D, Brown M, Dunn J, Mercado B, Hebda J, et al.
Chem Biol
. 2015 Mar;
22(3):369-78.
PMID: 25754474
Islet amyloid polypeptide (IAPP) is a hormone cosecreted with insulin. IAPP proceeds through a series of conformational changes from random coil to β-sheet via transient α-helical intermediates. An unknown subset...
30.
German E, Ross J, Knipe P, Don M, Thompson S, Hamilton A
Angew Chem Int Ed Engl
. 2015 Jan;
54(9):2649-52.
PMID: 25599889
Many therapeutically relevant protein-protein interactions contain hot-spot regions on secondary structural elements, which contribute disproportionately to binding enthalpy. Mimicry of such α-helical regions has met with considerable success, however the...