Andrei A Aleksandrov
Overview
Explore the profile of Andrei A Aleksandrov including associated specialties, affiliations and a list of published articles.
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23
Citations
1007
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Recent Articles
1.
McCravy M, Quinney N, Cholon D, Boyles S, Jensen T, Aleksandrov A, et al.
Eur Respir J
. 2020 Apr;
56(1).
PMID: 32265312
No abstract available.
2.
Patel W, Moore P, Sassano M, Lopes-Pacheco M, Aleksandrov A, Amaral M, et al.
Cell Mol Life Sci
. 2018 Dec;
76(5):977-994.
PMID: 30547226
The cystic fibrosis transmembrane conductance regulator (CFTR) is a cAMP-regulated, apical anion channel that regulates ion and fluid transport in many epithelia including the airways. We have previously shown that...
3.
Fay J, Aleksandrov L, Jensen T, Cui L, Kousouros J, He L, et al.
Biochemistry
. 2018 Oct;
57(43):6234-6246.
PMID: 30281975
The cystic fibrosis transmembrane conductance regulator (CFTR) anion channel, crucial to epithelial salt and water homeostasis, and defective due to mutations in its gene in patients with cystic fibrosis, is...
4.
Wang C, Aleksandrov A, Yang Z, Forouhar F, Proctor E, Kota P, et al.
J Biol Chem
. 2018 Jun;
293(46):17685-17704.
PMID: 29903914
Many disease-causing mutations impair protein stability. Here, we explore a thermodynamic strategy to correct the disease-causing F508del mutation in the human cystic fibrosis transmembrane conductance regulator (hCFTR). F508del destabilizes nucleotide-binding...
5.
Yang Z, Hildebrandt E, Jiang F, Aleksandrov A, Khazanov N, Zhou Q, et al.
Biochim Biophys Acta Biomembr
. 2018 Feb;
1860(5):1193-1204.
PMID: 29425673
The Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) is an ABC transporter containing two transmembrane domains forming a chloride ion channel, and two nucleotide binding domains (NBD1 and NBD2). CFTR has...
6.
Vernon R, Chong P, Lin H, Yang Z, Zhou Q, Aleksandrov A, et al.
J Biol Chem
. 2017 Jun;
292(34):14147-14164.
PMID: 28655774
Characterization of the second nucleotide-binding domain (NBD2) of the cystic fibrosis transmembrane conductance regulator (CFTR) has lagged behind research into the NBD1 domain, in part because NBD1 contains the F508del...
7.
Das J, Aleksandrov A, Cui L, He L, Riordan J, Dokholyan N
PLoS Comput Biol
. 2017 Jun;
13(6):e1005594.
PMID: 28640808
Mutations in the Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) gene affect CFTR protein biogenesis or its function as a chloride channel, resulting in dysregulation of epithelial fluid transport in the...
8.
Aleksandrov L, Jensen T, Cui L, Kousouros J, He L, Aleksandrov A, et al.
Protein Expr Purif
. 2015 Sep;
116:159-66.
PMID: 26384709
CFTR is unique among ABC transporters as the only one functioning as an ion channel and from a human health perspective because mutations in its gene cause cystic fibrosis. Although...
9.
Hildebrandt E, Ding H, Mulky A, Dai Q, Aleksandrov A, Bajrami B, et al.
Mol Biotechnol
. 2015 Mar;
57(5):406.
PMID: 25808031
No abstract available.
10.
Proctor E, Kota P, Aleksandrov A, He L, Riordan J, Dokholyan N
Chem Sci
. 2015 Feb;
6(2):1237-1246.
PMID: 25685315
Many cellular functions necessary for life are tightly regulated by protein allosteric conformational change, and correlated dynamics between protein regions has been found to contribute to the function of proteins...