Andreas Nolting
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Explore the profile of Andreas Nolting including associated specialties, affiliations and a list of published articles.
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Articles
7
Citations
133
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Recent Articles
1.
Ottosson N, Wu X, Nolting A, Karlsson U, Lund P, Ruda K, et al.
Sci Rep
. 2015 Aug;
5:13278.
PMID: 26299574
Voltage-gated ion channels generate cellular excitability, cause diseases when mutated, and act as drug targets in hyperexcitability diseases, such as epilepsy, cardiac arrhythmia and pain. Unfortunately, many patients do not...
2.
Klement G, Eisele L, Malinowsky D, Nolting A, Svensson M, Terp G, et al.
Biophys J
. 2013 Feb;
104(4):798-806.
PMID: 23442958
The pharmacology and regulation of Transient Receptor Potential Ankyrin 1 (TRPA1) ion channel activity is intricate due to the physiological function as an integrator of multiple chemical, mechanical, and temperature...
3.
Nyman E, Franzen B, Nolting A, Klement G, Liu G, Nilsson M, et al.
J Pain Res
. 2013 Feb;
6:59-70.
PMID: 23403691
AZ465 is a novel selective transient receptor potential cation channel, member A1 (TRPA1) antagonist identified during a focused drug discovery effort. In vitro, AZ465 fully inhibits activation by zinc, O-chlorobenzylidene...
4.
Vallin K, Sterky K, Nyman E, Bernstrom J, From R, Linde C, et al.
Bioorg Med Chem Lett
. 2012 Aug;
22(17):5485-92.
PMID: 22868228
A series of potent antagonists of the ion channel transient receptor potential A1 (TRPA1) was developed by modifying lead structure 16 that was discovered by high-throughput screening. Based on lead...
5.
Nolting A, Ferraro T, DHoedt D, Stocker M
J Biol Chem
. 2006 Dec;
282(6):3478-86.
PMID: 17142458
Small conductance calcium-activated potassium channels (SK, K(Ca)) are a family of voltage-independent K+ channels with a distinct physiology and pharmacology. The bee venom toxin apamin inhibits exclusively the three cloned...
6.
Ebbinghaus J, Legros C, Nolting A, Guette C, Celerier M, Pongs O, et al.
Toxicon
. 2004 Jun;
43(8):923-32.
PMID: 15208026
In order to find new peptide inhibitors for voltage-dependent potassium (Kv) channels, we examined the effects of venom from Theraphosa leblondi on Kv channel-mediated currents with the whole-cell patch-clamp technique....
7.
Gebauer M, Isbrandt D, Sauter K, Callsen B, Nolting A, Pongs O, et al.
Biophys J
. 2003 Dec;
86(1 Pt 1):210-23.
PMID: 14695263
We examined whether the N-terminus of Kv4.2 A-type channels (4.2NT) possesses an autoinhibitory N-terminal peptide domain, which, similar to the one of Shaker, mediates inactivation of the open state. We...