Andreas Kulik
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Explore the profile of Andreas Kulik including associated specialties, affiliations and a list of published articles.
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72
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1003
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Recent Articles
1.
Krysenko S, Emani C, Bauerle M, Oswald M, Kulik A, Meyners C, et al.
J Bacteriol
. 2025 Jan;
207(2):e0043924.
PMID: 39882905
Importance: Upon infection macrophages synthesize the polyamine spermine, which at elevated concentrations is toxic for . Based on our investigations of spermine resistance in the closely related actinomycete , we...
2.
Voitsekhovskaia I, Ho Y, Klatt C, Muller A, Machell D, Tan Y, et al.
RSC Chem Biol
. 2024 Sep;
PMID: 39247680
Glycopeptide antibiotics (GPAs) are peptide natural products used as last resort treatments for antibiotic resistant bacterial infections. They are produced by the sequential activities of a linear nonribosomal peptide synthetase...
3.
Giovannini S, Weibel L, Schittek B, Sinnberg T, Schaller M, Lemberg C, et al.
J Invest Dermatol
. 2024 Jul;
144(11):2465-2476.
PMID: 39047967
Phototoxicity and skin cancer are severe adverse effects of the anti-fungal drug voriconazole (VOR). These adverse effects resemble those seen in xeroderma pigmentosum, caused by defective DNA nucleotide excision repair...
4.
Hennrich O, Weinmann L, Kulik A, Harms K, Klahn P, Youn J, et al.
RSC Chem Biol
. 2023 Nov;
4(12):1050-1063.
PMID: 38033732
Streptogramins are the last line of defense antimicrobials with pristinamycin as a representative substance used as therapeutics against highly resistant pathogenic bacteria. However, the emergence of (multi)drug-resistant pathogens renders these...
5.
Beller P, Fink P, Wolf F, Mannle D, Helmle I, Kuttenlochner W, et al.
J Biol Chem
. 2023 Nov;
300(1):105507.
PMID: 38029966
Cystargolides are natural products originally isolated from Kitasatospora cystarginea NRRL B16505 as inhibitors of the proteasome. They are composed of a dipeptide backbone linked to a β-lactone warhead. Recently, we...
6.
Illigmann A, Vielberg M, Lakemeyer M, Wolf F, Dema T, Stange P, et al.
Angew Chem Int Ed Engl
. 2023 Nov;
63(3):e202314028.
PMID: 38029352
The caseinolytic protease is a highly conserved serine protease, crucial to prokaryotic and eukaryotic protein homeostasis, and a promising antibacterial and anticancer drug target. Herein, we describe the potent cystargolides...
7.
Goldfinger V, Spohn M, Rodler J, Sigle M, Kulik A, Cryle M, et al.
Metab Eng
. 2023 May;
78:84-92.
PMID: 37244369
Glycopeptide antibiotics (GPA) consist of a glycosylated heptapeptide backbone enriched in aromatic residues originating from the shikimate pathway. Since the enzymatic reactions within the shikimate pathway are highly feedback-regulated, this...
8.
Schafhauser T, Kulik A
Methods Mol Biol
. 2022 Nov;
2601:75-96.
PMID: 36445580
Antibiotic natural products from microbes are characterized by diverse and mostly complex chemical structures, which challenge their total chemical synthesis and make biotechnological production to the predominant production route. In...
9.
Bar D, Konetschny B, Kulik A, Xu H, Paccagnella D, Beller P, et al.
Microb Cell Fact
. 2022 Nov;
21(1):232.
PMID: 36335365
Background: Caprazamycins are liponucleoside antibiotics showing bioactivity against Gram-positive bacteria including clinically relevant Mycobacterium tuberculosis by targeting the bacterial MraY-translocase. Their chemical structure contains a unique 3-methylglutaryl moiety which they...
10.
Handel F, Kulik A, Wex K, Berscheid A, Saur J, Winkler A, et al.
NAR Genom Bioinform
. 2022 Jul;
4(3):lqac055.
PMID: 35855324
Today, one of the biggest challenges in antibiotic research is a targeted prioritization of natural compound producer strains and an efficient dereplication process to avoid undesired rediscovery of already known...