Andreas Bachmair
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Explore the profile of Andreas Bachmair including associated specialties, affiliations and a list of published articles.
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1316
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Recent Articles
1.
Stael S, Lois L, Bachmair A
Dev Cell
. 2025 Mar;
60(5):666-668.
PMID: 40068603
SUMOylation is a reversible post-translational modification that contributes to various biological processes in plants. In this issue of Developmental Cell, Zhang et al. show that covalent attachment of SUMO to...
2.
Julian J, Gao P, Del Chiaro A, Carlos De La Concepcion J, Armengot L, Somssich M, et al.
Nat Plants
. 2025 Feb;
11(2):321-339.
PMID: 39920307
Vacuoles are essential for cellular metabolism and growth and the maintenance of internal turgor pressure. They sequester lytic enzymes, ions and secondary metabolites that, if leaked into the cytosol, could...
3.
Rudi O, Hodakova Z, Farias Saad C, Winter N, Grishkovskaya I, Bohm J, et al.
J Mol Biol
. 2025 Jan;
437(4):168939.
PMID: 39799992
N-degrons are amino-terminal degradation signals. Non-acetylated first residues with bulky side chains were the first discovered N-degrons. In yeast, their ability to destabilize a protein depends on ubiquitin ligase Ubr1,...
4.
Zhang H, Rundle C, Winter N, Miricescu A, Mooney B, Bachmair A, et al.
Plant Cell
. 2024 Apr;
36(9):3177-3200.
PMID: 38608155
BIG/DARK OVEREXPRESSION OF CAB1/TRANSPORT INHIBITOR RESPONSE3 is a 0.5 MDa protein associated with multiple functions in Arabidopsis (Arabidopsis thaliana) signaling and development. However, the biochemical functions of BIG are unknown....
5.
Bohm J, Winter N, Kozlic A, Telser T, Nehlin L, Bachmair A
Methods Enzymol
. 2023 Aug;
686:221-233.
PMID: 37532401
Heterologous expression of enzymes can generate a background-free environment that facilitates investigation of enzyme properties, for instance to focus on particular isoforms in case of gene families, or on individual...
6.
Tomanov K, Julian J, Ziba I, Bachmair A
Methods Mol Biol
. 2022 Nov;
2581:83-92.
PMID: 36413312
SUMO conjugation is a conserved process of eukaryotes, and essential in metazoa. Similar to ubiquitylation, a SUMO-activating enzyme links to the SUMO carboxyl-terminal Gly in a thioester bond, and a...
7.
Talloji P, Nehlin L, Huttel B, Winter N, Cerny M, Dufkova H, et al.
BMC Plant Biol
. 2022 Apr;
22(1):183.
PMID: 35395773
Background: Many regulatory circuits in plants contain steps of targeted proteolysis, with the ubiquitin proteasome system (UPS) as the mediator of these proteolytic events. In order to decrease ubiquitin-dependent proteolysis,...
8.
Kozlic A, Winter N, Telser T, Reimann J, Rose K, Nehlin L, et al.
Front Plant Sci
. 2022 Jan;
12:806129.
PMID: 35069663
The N-degron pathway is a branch of the ubiquitin-proteasome system where amino-terminal residues serve as degradation signals. In a synthetic biology approach, we expressed ubiquitin ligase PRT6 and ubiquitin conjugating...
9.
Winter N, Novatchkova M, Bachmair A
Int J Mol Sci
. 2021 Apr;
22(7).
PMID: 33805528
The first amino acid of a protein has an important influence on its metabolic stability. A number of ubiquitin ligases contain binding domains for different amino-terminal residues of their substrates,...
10.
Millar A, Heazlewood J, Giglione C, Holdsworth M, Bachmair A, Schulze W
Annu Rev Plant Biol
. 2019 Feb;
70:119-151.
PMID: 30786234
Assessing posttranslational modification (PTM) patterns within protein molecules and reading their functional implications present grand challenges for plant biology. We combine four perspectives on PTMs and their roles by considering...