Andrea R Nawrocki
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Explore the profile of Andrea R Nawrocki including associated specialties, affiliations and a list of published articles.
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Articles
33
Citations
1655
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Recent Articles
1.
Frikke-Schmidt H, Albarazanji K, Qi J, Frederick D, Steffen J, Kalyana-Sundaram S, et al.
J Pharmacol Exp Ther
. 2025 Mar;
392(2):100002.
PMID: 40023580
Acute kidney injury (AKI) is characterized by an abrupt decline in kidney function and has been associated with excess risks of death, kidney disease progression, and cardiovascular events. The kidney...
2.
Li C, Sun X, Funcke J, Vanharanta L, Joffin N, Li Y, et al.
bioRxiv
. 2024 Aug;
PMID: 39211078
Adipogenin (Adig) is an evolutionarily conserved microprotein and is highly expressed in adipose tissues and testis. Here, we identify Adig as a critical regulator for lipid droplet formation in adipocytes....
3.
Zhai Y, Chavez J, DAquino K, Meng R, Nawrocki A, Pocai A, et al.
Am J Physiol Cell Physiol
. 2024 Mar;
326(5):C1423-C1436.
PMID: 38497113
Nicotinamide adenine dinucleotide (NAD) is a pivotal coenzyme, essential for cellular reactions, metabolism, and mitochondrial function. Depletion of kidney NAD levels and reduced de novo NAD synthesis through the tryptophan-kynurenine...
4.
Zheng S, Polidori D, Wang Y, Geist B, Lin-Schmidt X, Furman J, et al.
Clin Transl Sci
. 2023 May;
16(8):1431-1444.
PMID: 37154518
Growth Differentiation Factor-15 (GDF15) is a circulating polypeptide linked to cellular stress and metabolic adaptation. GDF15's half-life is ~3 h and activates the glial cell line-derived neurotrophic factor family receptor...
5.
Wang X, Li Q, Du F, Shukla N, Nawrocki A, Chintala M
TH Open
. 2023 Apr;
7(2):e97-e104.
PMID: 37101592
Factor XIa (FXIa) is an emerging therapeutic target, and FXIa inhibition is a promising mechanism to improve therapeutic index over current anticoagulants. Milvexian (BMS-986177/JNJ-70033093) is an oral small-molecule FXIa inhibitor. ...
6.
Camacho R, Polidori D, Chen T, Chen B, Han Hsu H, Gao B, et al.
Diabetes Obes Metab
. 2022 Dec;
25(4):1068-1079.
PMID: 36546607
Aim: To develop an obese, insulin-resistant cynomolgus monkey model of non-alcoholic steatohepatitis (NASH) with fibrosis with a high fat/high cholesterol (HFHC) diet (with or without high fructose) and test its...
7.
Palani A, Nawrocki A, Orvieto F, Bianchi E, Mandic E, Pessi A, et al.
ACS Med Chem Lett
. 2022 Aug;
13(8):1248-1254.
PMID: 35978682
Peptide-based analogues of the gut-derived incretin hormone, glucagon-like peptide 1 (GLP1), stimulate insulin secretion in a glucose-dependent manner. Currently marketed GLP1 receptor (GLP1R) agonists are safe and effective in the...
8.
Steffen J, Ngo J, Wang S, Williams K, Kramer H, Ho G, et al.
Mol Metab
. 2022 Aug;
64:101566.
PMID: 35940556
Objective: The mitochondrial fission protein Drp1 was proposed to promote NAFLD, as inhibition of hepatocyte Drp1 early in life prevents liver steatosis induced by high-fat diet in mice. However, whether...
9.
Albarazanji K, Nawrocki A, Gao B, Wang X, Wang Y, Xiao Y
Sci Rep
. 2021 Jun;
11(1):11866.
PMID: 34088949
Meal ingestion elicits a variety of neuronal, physiological and hormonal responses that differ in healthy, obese or diabetic individuals. The mixed meal tolerance test (MMTT) is a well-established method to...
10.
Muise E, Guan H, Liu J, Nawrocki A, Yang X, Wang C, et al.
PLoS One
. 2019 Feb;
14(2):e0211568.
PMID: 30811418
Physical activity promotes metabolic and cardiovascular health benefits that derive in part from the transcriptional responses to exercise that occur within skeletal muscle and other organs. There is interest in...