Andrea Medeiros
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Explore the profile of Andrea Medeiros including associated specialties, affiliations and a list of published articles.
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Articles
35
Citations
261
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Recent Articles
1.
Rivas F, Del Marmol C, Scalese G, Perez Diaz L, Machado I, Blacque O, et al.
Inorg Chem
. 2024 Jun;
63(25):11667-11687.
PMID: 38860314
Human African trypanosomiasis (HAT, sleeping sickness) and American trypanosomiasis (Chagas disease) are endemic zoonotic diseases caused by genomically related trypanosomatid protozoan parasites ( and , respectively). Just a few old...
2.
Dibello E, Oddone N, Franco J, Illyes T, Medeiros A, Kiss A, et al.
Int J Parasitol Drugs Drug Resist
. 2024 Mar;
24:100529.
PMID: 38461700
Earlier evidences showed that diglycosyl diselenides are active against the infective stage of African trypanosomes (top hits IC 0.5 and 1.5 μM) but poorly selective (selectivity index <10). Here we...
3.
Ruatta S, Prada Gori D, Flo Diaz M, Lorenzelli F, Perelmuter K, Alberca L, et al.
Front Pharmacol
. 2023 Jul;
14:1193282.
PMID: 37426813
The identification of chemical compounds that interfere with SARS-CoV-2 replication continues to be a priority in several academic and pharmaceutical laboratories. Computational tools and approaches have the power to integrate,...
4.
Daghero H, Pagotto R, Quiroga C, Medeiros A, Comini M, Bollati-Fogolin M
Front Cell Infect Microbiol
. 2023 Mar;
13:1082524.
PMID: 36968103
Chagas disease (CD) is a life-threatening illness caused by the parasite (). With around seven million people infected worldwide and over 50,000 deaths per year, CD is a major public...
5.
Rivas F, Del Marmol C, Scalese G, Perez-Diaz L, Machado I, Blacque O, et al.
J Inorg Biochem
. 2022 Oct;
237:112016.
PMID: 36244312
Human African trypanosomiasis (sleeping sickness) and leishmaniasis are prevalent zoonotic diseases caused by genomically related trypanosomatid protozoan parasites (Trypanosoma brucei and Leishmania spp). Additionally, both are co-endemic in certain regions...
6.
Barreiro-Costa O, Quiroga Lozano C, Munoz E, Rojas-Silva P, Medeiros A, Comini M, et al.
Biomedicines
. 2022 Aug;
10(8).
PMID: 36009460
Trypanosomiasis and leishmaniasis are neglected infections caused by trypanosomatid parasites. The first-line treatments have many adverse effects, high costs, and are prone to resistance development, hence the necessity for new...
7.
Benitez D, Medeiros A, Quiroga C, Comini M
Methods Mol Biol
. 2022 Jul;
2524:127-147.
PMID: 35821468
This chapter describes a viability assay for the intracellular (amastigote) and clinically relevant form of Leishmania infantum that is based on the detection of bioluminescence (BL) signal. The assay uses...
8.
Rivas F, Medeiros A, Quiroga C, Benitez D, Comini M, Rodriguez-Arce E, et al.
Dalton Trans
. 2021 Jan;
50(5):1651-1665.
PMID: 33449983
In the search for a more effective chemotherapy for the treatment of Human African Trypanosomiasis, a disease caused by the parasite Trypanosoma brucei, the development of ferrocenyl compounds has arisen...
9.
Medeiros A, Benitez D, Korn R, Ferreira V, Barrera E, Carrion F, et al.
J Enzyme Inhib Med Chem
. 2020 Jun;
35(1):1345-1358.
PMID: 32588679
Trypanothione synthetase (TryS) produces -bis(glutathionyl)spermidine (or trypanothione) at the expense of ATP. Trypanothione is a metabolite unique and essential for survival and drug-resistance of trypanosomatid parasites. In this study, we...
10.
Vairoletti F, Medeiros A, Fontan P, Melendrez J, Tabarez C, Salinas G, et al.
Medchemcomm
. 2019 Nov;
10(8):1481-1487.
PMID: 31673311
1,4-Thiazepines derivatives are pharmacologically important heterocycles with different applications in medicinal chemistry. In the present work, we describe the preparation of new bicyclic thiazolidinyl-1,4-thiazepines by reaction between azadithiane compounds and...