Andrea G Cochran
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Explore the profile of Andrea G Cochran including associated specialties, affiliations and a list of published articles.
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38
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1633
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Recent Articles
1.
Cochran A, Flynn M
J Med Chem
. 2023 Sep;
66(18):13116-13134.
PMID: 37702400
Bromodomains are acetyl-lysine binding modules that are found in different classes of chromatin-interacting proteins. Among these are large chromatin remodeling complexes such as BAF and PBAF (variants of human SWI/SNF)....
2.
Taylor A, Bailey C, Belmont L, Campbell R, Cantone N, Cote A, et al.
J Med Chem
. 2022 Aug;
65(16):11177-11186.
PMID: 35930799
Bromodomains are acetyllysine recognition domains present in a variety of human proteins. Bromodomains also bind small molecules that compete with acetyllysine, and therefore bromodomains have been targets for drug discovery...
3.
Miller G, Flynn E, Tom J, Song A, Cochran A
ACS Chem Biol
. 2022 Apr;
17(5):1022-1029.
PMID: 35467836
Genetic code expansion has proven invaluable to the elucidation of functions of defined protein modifications through the site-specific incorporation of noncanonical amino acids. The use of nonhydrolyzable derivatives of post-translational...
4.
Cochran A, Conery A, Sims 3rd R
Nat Rev Drug Discov
. 2019 Jul;
18(8):609-628.
PMID: 31273347
Less than a decade ago, it was shown that bromodomains, acetyl lysine 'reader' modules found in proteins with varied functions, were highly tractable small-molecule targets. This is an unusual property...
5.
Wang S, Tsui V, Crawford T, Audia J, Burdick D, Beresini M, et al.
J Med Chem
. 2018 Oct;
61(20):9301-9315.
PMID: 30289257
The biological functions of the dual bromodomains of human transcription-initiation-factor TFIID subunit 1 (TAF1(1,2)) remain unknown, although TAF1 has been identified as a potential target for oncology research. Here, we...
6.
Oppikofer M, Sagolla M, Haley B, Zhang H, Kummerfeld S, Sudhamsu J, et al.
Nat Commun
. 2017 Oct;
8(1):862.
PMID: 29021563
Members of the ISWI family of chromatin remodelers mobilize nucleosomes to control DNA accessibility and, in some cases, are required for recovery from DNA damage. However, it remains poorly understood...
7.
Oppikofer M, Bai T, Gan Y, Haley B, Liu P, Sandoval W, et al.
EMBO Rep
. 2017 Aug;
18(10):1697-1706.
PMID: 28801535
ISWI chromatin remodelers mobilize nucleosomes to control DNA accessibility. Complexes isolated to date pair one of six regulatory subunits with one of two highly similar ATPases. However, we find that...
8.
Crawford T, Audia J, Bellon S, Burdick D, Bommi-Reddy A, Cote A, et al.
ACS Med Chem Lett
. 2017 Jul;
8(7):737-741.
PMID: 28740608
The biological function of bromodomains, epigenetic readers of acetylated lysine residues, remains largely unknown. Herein we report our efforts to discover a potent and selective inhibitor of the bromodomain of...
9.
Crawford T, Vartanian S, Cote A, Bellon S, Duplessis M, Flynn E, et al.
Bioorg Med Chem Lett
. 2017 Jun;
27(15):3534-3541.
PMID: 28606761
Bromodomain-containing protein 9 (BRD9), an epigenetic "reader" of acetylated lysines on post-translationally modified histone proteins, is upregulated in multiple cancer cell lines. To assess the functional role of BRD9 in...
10.
Crawford T, Romero F, Lai K, Tsui V, Taylor A, De Leon Boenig G, et al.
J Med Chem
. 2016 Sep;
59(23):10549-10563.
PMID: 27682507
The single bromodomain of the closely related transcriptional regulators CBP/EP300 is a target of much recent interest in cancer and immune system regulation. A co-crystal structure of a ligand-efficient screening...