Andrea Foley
Overview
Explore the profile of Andrea Foley including associated specialties, affiliations and a list of published articles.
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Articles
14
Citations
1058
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0
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Recent Articles
1.
Bolukbasi E, Woodling N, Ivanov D, Adcott J, Foley A, Rajasingam A, et al.
Proc Natl Acad Sci U S A
. 2021 Feb;
118(8).
PMID: 33593901
Reduced activity of insulin/insulin-like growth factor signaling (IIS) increases healthy lifespan among diverse animal species. Downstream of IIS, multiple evolutionarily conserved transcription factors (TFs) are required; however, distinct TFs are...
2.
Bjedov I, Cocheme H, Foley A, Wieser D, Woodling N, Castillo-Quan J, et al.
PLoS Genet
. 2020 Nov;
16(11):e1009083.
PMID: 33253201
Increased cellular degradation by autophagy is a feature of many interventions that delay ageing. We report here that increased autophagy is necessary for reduced insulin-like signalling (IIS) to extend lifespan...
3.
van Dam E, van Leeuwen L, Dos Santos E, James J, Best L, Lennicke C, et al.
Cell Metab
. 2020 Mar;
31(4):710-725.e7.
PMID: 32197072
High-sugar diets cause thirst, obesity, and metabolic dysregulation, leading to diseases including type 2 diabetes and shortened lifespan. However, the impact of obesity and water imbalance on health and survival...
4.
Slack C, Alic N, Foley A, Cabecinha M, Hoddinott M, Partridge L
Cell
. 2015 Jun;
162(1):72-83.
PMID: 26119340
Identifying the molecular mechanisms that underlie aging and their pharmacological manipulation are key aims for improving lifelong human health. Here, we identify a critical role for Ras-Erk-ETS signaling in aging...
5.
Foley A
Home Healthc Nurse
. 2013 Jan;
31(3):127-33.
PMID: 23314203
This article is a review of relevant literature exploring the factors that contribute to new graduate nurses' transition to home healthcare nursing. The results revealed themes that include introducing the...
6.
Slack C, Foley A, Partridge L
PLoS One
. 2012 Oct;
7(10):e47699.
PMID: 23077661
The biguanide drug, metformin, commonly used to treat type-2 diabetes, has been shown to extend lifespan and reduce fecundity in C. elegans through a dietary restriction-like mechanism via the AMP-activated...
7.
Alic N, Hoddinott M, Foley A, Slack C, Piper M, Partridge L
PLoS One
. 2012 Oct;
7(9):e45367.
PMID: 23028964
RNA interference (RNAi) provides an important tool for gene function discovery. It has been widely exploited in Caenorhabditis elegans ageing research because it does not appear to have any non-specific...
8.
Slack C, Giannakou M, Foley A, Goss M, Partridge L
Aging Cell
. 2011 Mar;
10(5):735-48.
PMID: 21443682
The insulin/insulin-like growth factor-like signaling (IIS) pathway in metazoans has evolutionarily conserved roles in growth control, metabolic homeostasis, stress responses, reproduction, and lifespan. Genetic manipulations that reduce IIS in the...
9.
Slack C, Werz C, Wieser D, Alic N, Foley A, Stocker H, et al.
PLoS Genet
. 2010 Mar;
6(3):e1000881.
PMID: 20333234
Drosophila Lnk is the single ancestral orthologue of a highly conserved family of structurally-related intracellular adaptor proteins, the SH2B proteins. As adaptors, they lack catalytic activity but contain several protein-protein...
10.
Bjedov I, Toivonen J, Kerr F, Slack C, Jacobson J, Foley A, et al.
Cell Metab
. 2010 Jan;
11(1):35-46.
PMID: 20074526
The target of rapamycin (TOR) pathway is a major nutrient-sensing pathway that, when genetically downregulated, increases life span in evolutionarily diverse organisms including mammals. The central component of this pathway,...