Andrea Denardo
Overview
Explore the profile of Andrea Denardo including associated specialties, affiliations and a list of published articles.
Author names and details appear as published. Due to indexing inconsistencies, multiple individuals may share a name, and a single author may have variations. MedLuna displays this data as publicly available, without modification or verification
Snapshot
Snapshot
Articles
15
Citations
96
Followers
0
Related Specialties
Related Specialties
Top 10 Co-Authors
Top 10 Co-Authors
Published In
Published In
Affiliations
Affiliations
Soon will be listed here.
Recent Articles
1.
Gangemi R, Bignotti M, Denardo A, Pearce C, Ronzoni R, Lomas D, et al.
FEBS J
. 2025 Jan;
PMID: 39777987
Neutrophil elastase (NE) is released by activated neutrophils during an inflammatory response and exerts proteolytic activity on elastin and other extracellular matrix components. This protease is rapidly inhibited by the...
2.
Asperti M, Denardo A, Gryzik M, Persson K, Westerberg G, Ohd J, et al.
Hemasphere
. 2024 Dec;
8(12):e70035.
PMID: 39619244
Hepcidin is an essential regulator of systemic iron availability mediating both iron uptake from the diet and its release from body stores. Abnormally high hepcidin levels resulting from inflammation in...
3.
Balderacchi A, Bignotti M, Ottaviani S, Denardo A, Barzon V, Ben Khlifa E, et al.
Clin Chem Lab Med
. 2024 Feb;
62(10):1980-1990.
PMID: 38407261
Objectives: Alpha-1-antitrypsin deficiency is a genetic disorder caused by mutations in the gene encoding alpha-1-antitrypsin (AAT), the major serine protease inhibitor in plasma. Reduced AAT levels are associated with elevated...
4.
Denardo A, Ben Khlifa E, Bignotti M, Fra A
Methods Mol Biol
. 2023 Dec;
2750:79-93.
PMID: 38108969
Advances in genetic screening technologies have considerably accelerated the discovery of rare alpha-1-antitrypsin (AAT) variants. Expression in cellular models is an effective approach to evaluate the pathogenic potential of these...
5.
Denardo A, Ben Khlifa E, Bignotti M, Giuliani R, DAcunto E, Miranda E, et al.
Cell Mol Life Sci
. 2023 Dec;
81(1):6.
PMID: 38087060
Lung disease in alpha-1-antitrypsin deficiency (AATD) mainly results from insufficient control of the serine proteases neutrophil elastase (NE) and proteinase-3 due to reduced plasma levels of alpha-1-antitrypsin (AAT) variants. Mutations...
6.
Asperti M, Cantamessa L, Gryzik M, Bugatti M, Codenotti S, Denardo A, et al.
Clin Exp Med
. 2023 Feb;
23(6):2487-2502.
PMID: 36764998
Rhabdomyosarcoma (RMS) is an aggressive rare neoplasm that derives from mesenchymal cells, which frequently develops resistance to the current therapies and the formation of metastases. Thus, new therapies are needed....
7.
Asperti M, Brilli E, Denardo A, Gryzik M, Pagani F, Busti F, et al.
Am J Hematol
. 2021 Aug;
96(10):1253-1263.
PMID: 34343368
Iron-refractory iron deficiency anemia (IRIDA) is an autosomal recessive disorder caused by genetic mutations on TMPRSS6 gene which encodes Matriptase2 (MT2). An altered MT2 cannot appropriately suppress hepatic BMP6/SMAD signaling...
8.
Sandoval D, Clausen T, Nora C, Cribbs A, Denardo A, Clark A, et al.
bioRxiv
. 2021 Apr;
PMID: 33791697
We identify the prolyl-tRNA synthetase (PRS) inhibitor halofuginone , a compound in clinical trials for anti-fibrotic and anti-inflammatory applications , as a potent inhibitor of SARS-CoV-2 infection and replication. The...
9.
NCOA4-mediated ferritinophagy promotes ferroptosis induced by erastin, but not by RSL3 in HeLa cells
Gryzik M, Asperti M, Denardo A, Arosio P, Poli M
Biochim Biophys Acta Mol Cell Res
. 2020 Nov;
1868(2):118913.
PMID: 33245979
Ferroptosis is a regulated cell death characterized by a lethal accumulation of lipid peroxides due to an increase of intracellular iron and a decrease of antioxidant capacity. The reduction of...
10.
Denardo A, Elli S, Federici S, Asperti M, Gryzik M, Ruzzenenti P, et al.
Biochim Biophys Acta Gen Subj
. 2020 Nov;
1865(2):129799.
PMID: 33232799
Background: The bone morphogenetic protein 6 (BMP6) is a crucial inducer of hepcidin, the peptide hormone that regulates the iron availability in our body. Hepcidin expression is influenced by hepatic...