Andrea Crotti
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Explore the profile of Andrea Crotti including associated specialties, affiliations and a list of published articles.
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18
Citations
1467
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Recent Articles
1.
Ling Y, Crotti A
Adv Neurobiol
. 2024 Aug;
37:623-637.
PMID: 39207717
Modulation of microglia function for treatment of neurodegenerative and neuropsychiatric disorders is an emerging field of neuroscience drug development. This is largely attributed to human genetic association studies combined with...
2.
Taga M, Petyuk V, White C, Marsh G, Ma Y, Klein H, et al.
Mol Neurodegener
. 2020 Jul;
15(1):44.
PMID: 32727516
Background: Identified as an Alzheimer's disease (AD) susceptibility gene by genome wide-association studies, BIN1 has 10 isoforms that are expressed in the Central Nervous System (CNS). The distribution of these...
3.
McAvoy K, Rajamohamed Sait H, Marsh G, Peterson M, Reynolds T, Gagnon J, et al.
PLoS One
. 2019 Aug;
14(8):e0220125.
PMID: 31408457
BIN1 is the most important risk locus for Late Onset Alzheimer's Disease (LOAD), after ApoE. BIN1 AD-associated SNPs correlate with Tau deposition as well as with brain atrophy. Furthermore, the...
4.
Crotti A, Sait H, McAvoy K, Estrada K, Ergun A, Szak S, et al.
Sci Rep
. 2019 Jul;
9(1):9477.
PMID: 31263146
Despite Bridging INtegrator 1 (BIN1) being the second most statistically-significant locus associated to Late Onset Alzheimer's Disease, its role in disease pathogenesis remains to be clarified. As reports suggest a...
5.
Ajami B, Samusik N, Wieghofer P, Ho P, Crotti A, Bjornson Z, et al.
Nat Neurosci
. 2018 Mar;
21(4):541-551.
PMID: 29507414
Neuroinflammation and neurodegeneration may represent two poles of brain pathology. Brain myeloid cells, particularly microglia, play key roles in these conditions. We employed single-cell mass cytometry (CyTOF) to compare myeloid...
6.
Crotti A, Ransohoff R
Immunity
. 2016 Mar;
44(3):505-515.
PMID: 26982357
Microglia originate from erythromyeloid progenitors (EMPs) in the yolk sac and develop in the forming CNS. Microglia are fundamental for the development and function of a healthy brain. By contrast,...
7.
Crotti A, Glass C
Trends Immunol
. 2015 May;
36(6):364-73.
PMID: 26001312
Currently, the concept of 'neuroinflammation' includes inflammation associated with neurodegenerative diseases, in which there is little or no infiltration of blood-derived immune cells into the brain. The roles of brain-resident...
8.
Crotti A, Benner C, Kerman B, Gosselin D, Lagier-Tourenne C, Zuccato C, et al.
Nat Neurosci
. 2014 Mar;
17(4):513-21.
PMID: 24584051
Huntington's disease (HD) is a fatal neurodegenerative disorder caused by an extended polyglutamine repeat in the N terminus of the Huntingtin protein (HTT). Reactive microglia and elevated cytokine levels are...
9.
Shibata N, Carlin A, Spann N, Saijo K, Morello C, McDonald J, et al.
J Biol Chem
. 2013 Nov;
288(50):35812-23.
PMID: 24189069
25-Hydroxycholesterol (25OHC) is an enzymatically derived oxidation product of cholesterol that modulates lipid metabolism and immunity. 25OHC is synthesized in response to interferons and exerts broad antiviral activity by as...
10.
Saijo K, Crotti A, Glass C
Glia
. 2012 Sep;
61(1):104-11.
PMID: 22987512
Microglia cells function as sentinels for innate immunity in the central nervous system (CNS). To perform this function, microglia express a diverse set of pattern recognition receptors (PRRs) for pathogen-associated...