Richard M Ransohoff
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Explore the profile of Richard M Ransohoff including associated specialties, affiliations and a list of published articles.
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317
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36211
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Recent Articles
1.
Vicario R, Fragkogianni S, Weber L, Lazarov T, Hu Y, Hayashi S, et al.
Elife
. 2025 Mar;
13.
PMID: 40085681
Somatic genetic heterogeneity resulting from post-zygotic DNA mutations is widespread in human tissues and can cause diseases, however, few studies have investigated its role in neurodegenerative processes such as Alzheimer's...
2.
Ransohoff R
Neurol Neuroimmunol Neuroinflamm
. 2024 Dec;
12(1):e200352.
PMID: 39671535
Neurologic disease remains a cause of incalculable suffering, a formidable public health burden, and a wilderness of complex biology and medicine. At the same time, advances in basic science, technology,...
3.
Pereira-Iglesias M, Maldonado-Teixido J, Melero A, Piriz J, Galea E, Ransohoff R, et al.
Nat Neurosci
. 2024 Dec;
28(1):15-23.
PMID: 39663381
Over a decade ago, it was discovered that microglia, the brain's immune cells, engulf synaptic material in a process named microglial pruning. This term suggests that microglia actively sculpt brain...
4.
Heneka M, van der Flier W, Jessen F, Hoozemanns J, Thal D, Boche D, et al.
Nat Rev Immunol
. 2024 Dec;
PMID: 39653749
Increasing evidence points to a pivotal role of immune processes in the pathogenesis of Alzheimer disease, which is the most prevalent neurodegenerative and dementia-causing disease of our time. Multiple lines...
5.
Zhu B, Wangzhou A, Yu D, Li T, Schmidt R, De Florencio S, et al.
bioRxiv
. 2024 Oct;
PMID: 39464012
Germline genetic architecture of Alzheimer's disease (AD) indicates microglial mechanisms of disease susceptibility and outcomes. However, the mechanisms that enable microglia to mediate protective responses to AD pathology remain elusive....
6.
Ransohoff R
Trends Immunol
. 2024 Oct;
45(11):849-850.
PMID: 39395883
Gao, Kim, and colleagues recently reported that clonal populations of CD4 T cells could be detected in mice that underwent spinal cord injury (SCI). A subset of clones mediated enhanced...
7.
Sierra A, Miron V, Paolicelli R, Ransohoff R
Cold Spring Harb Perspect Biol
. 2024 Mar;
16(8).
PMID: 38438189
Microglia are usually referred to as "the innate immune cells of the brain," "the resident macrophages of the central nervous system" (CNS), or "CNS parenchymal macrophages." These labels allude to...
8.
Vicario R, Fragkogianni S, Weber L, Lazarov T, Hu Y, Hayashi S, et al.
bioRxiv
. 2024 Feb;
PMID: 38328106
Somatic genetic heterogeneity resulting from post-zygotic DNA mutations is widespread in human tissues and can cause diseases, however few studies have investigated its role in neurodegenerative processes such as Alzheimer's...
9.
Garofalo S, Cocozza G, Mormino A, Bernardini G, Russo E, Ielpo D, et al.
Nat Commun
. 2023 May;
14(1):3103.
PMID: 37248289
The mechanisms of communication between the brain and the immune cells are still largely unclear. Here, we characterize the populations of resident natural killer (NK) cells and innate lymphoid cells...
10.
Church K, Rodriguez D, Mendiola A, Vanegas D, Gutierrez I, Tamayo I, et al.
Front Immunol
. 2023 Apr;
14:1130735.
PMID: 37033925
Diabetic retinopathy, a microvascular disease characterized by irreparable vascular damage, neurodegeneration and neuroinflammation, is a leading complication of diabetes mellitus. There is no cure for DR, and medical interventions marginally...