Andrea Becchetti
Overview
Explore the profile of Andrea Becchetti including associated specialties, affiliations and a list of published articles.
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74
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1389
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Recent Articles
1.
Duranti C, Iorio J, Manganelli V, Bagni G, Colasurdo R, Lottini T, et al.
Cell Death Discov
. 2025 Feb;
11(1):39.
PMID: 39900574
Plasma membrane macromolecular complexes function as signaling hubs that regulate cell behavior, which is particularly relevant in cancer. Our study provides evidence that the complex formed by the hERG1 potassium...
2.
Crociani O, Zanieri F, Pillozzi S, Lastraioli E, Stefanini M, Fiore A, et al.
Sci Rep
. 2025 Jan;
15(1):3550.
PMID: 39875549
No abstract available.
3.
Lastraioli E, Iorio J, Piazza F, Capitani C, Santillo M, Duranti C, et al.
Cancer Cell Int
. 2025 Jan;
25(1):24.
PMID: 39865220
Background: Mounting evidence underline the relevance of macromolecular complexes in cancer. Integrins frequently recruit ion channels and transporters within complexes which behave as signaling hubs. A complex composed by β1...
4.
Bandarabadi M, Li S, Aeschlimann L, Colombo G, Tzanoulinou S, Tafti M, et al.
Mol Psychiatry
. 2023 Dec;
29(2):327-341.
PMID: 38123729
Hypocretin/Orexin (HCRT/OX) and dopamine (DA) are both key effectors of salience processing, reward and stress-related behaviors and motivational states, yet their respective roles and interactions are poorly delineated. We inactivated...
5.
Becchetti A
Curr Top Membr
. 2023 Nov;
92:15-46.
PMID: 38007266
The cytoplasmic Ca concentration and the activity of K channels on the plasma membrane regulate cellular processes ranging from mitosis to oriented migration. The interplay between Ca and K signals...
6.
Duranti C, Iorio J, Bagni G, Chioccioli Altadonna G, Fillion T, Lulli M, et al.
Life Sci Alliance
. 2023 Nov;
7(1).
PMID: 37923359
The hERG1 potassium channel is aberrantly over expressed in tumors and regulates the cancer cell response to integrin-dependent adhesion. We unravel a novel signaling pathway by which integrin engagement by...
7.
Montalbano A, Sala C, Chioccioli Altadonna G, Becchetti A, Arcangeli A
Heliyon
. 2023 Sep;
9(10):e20112.
PMID: 37767500
Pharmacological studies aimed at the development of newly synthesized drugs directed against ion channels (as well as genetic studies of ion channel mutations) involve the development and use of transfected...
8.
Gubic S, Montalbano A, Sala C, Becchetti A, Hendrickx L, Van Theemsche K, et al.
Eur J Med Chem
. 2023 Jul;
259:115561.
PMID: 37454520
Voltage-gated potassium channel K1.3 inhibitors have been shown to be effective in preventing T-cell proliferation and activation by affecting intracellular Ca homeostasis. Here, we present the structure-activity relationship, K1.3 inhibition,...
9.
Becchetti A, Grandi L, Cerina M, Amadeo A
Pharmacol Res
. 2023 Feb;
189:106698.
PMID: 36796465
Despite recent advances in understanding the causes of epilepsy, especially the genetic, comprehending the biological mechanisms that lead to the epileptic phenotype remains difficult. A paradigmatic case is constituted by...
10.
Chioccioli Altadonna G, Montalbano A, Iorio J, Becchetti A, Arcangeli A, Duranti C
Membranes (Basel)
. 2022 Nov;
12(11).
PMID: 36422154
Ion channels are implicated in various diseases, including cancer, in which they modulate different aspects of cancer progression. In particular, potassium channels are often aberrantly expressed in cancers, a major...