Andre Leier
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Explore the profile of Andre Leier including associated specialties, affiliations and a list of published articles.
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53
Citations
1503
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Recent Articles
1.
Weiner E, Berryman E, Frey F, Solis A, Leier A, Lago T, et al.
Proc Natl Acad Sci U S A
. 2024 Oct;
121(44):e2409407121.
PMID: 39441629
Multivesicular endosomes (MVEs) sequester membrane proteins destined for degradation within intralumenal vesicles (ILVs), a process mediated by the membrane-remodeling action of Endosomal Sorting Complex Required for Transport (ESCRT) proteins. In...
2.
Staedtke V, Anstett K, Bedwell D, Giovannini M, Keeling K, Kesterson R, et al.
Clin Trials
. 2023 Nov;
21(1):51-66.
PMID: 37937606
Numerous successful gene-targeted therapies are arising for the treatment of a variety of rare diseases. At the same time, current treatment options for neurofibromatosis 1 and schwannomatosis are limited and...
3.
Chen J, Shrestha L, Green G, Leier A, Marquez-Lago T
Brief Bioinform
. 2023 Jan;
24(1).
PMID: 36617463
DNA and RNA sequencing technologies have revolutionized biology and biomedical sciences, sequencing full genomes and transcriptomes at very high speeds and reasonably low costs. RNA sequencing (RNA-Seq) enables transcript identification...
4.
Chen Z, Liu X, Li F, Li C, Marquez-Lago T, Leier A, et al.
Methods Mol Biol
. 2022 Jun;
2499:205-219.
PMID: 35696083
Among various types of protein post-translational modifications (PTMs), lysine PTMs play an important role in regulating a wide range of functions and biological processes. Due to the generation and accumulation...
5.
Leier A, Moore M, Liu H, Daniel M, Hyde A, Messiaen L, et al.
Mol Ther Nucleic Acids
. 2022 Apr;
28:261-278.
PMID: 35433111
We investigated the feasibility of utilizing an exon-skipping approach as a genotype-dependent therapeutic for neurofibromatosis type 1 (NF1) by determining which exons might be skipped while maintaining neurofibromin protein expression...
6.
Chen J, Li F, Wang M, Li J, Marquez-Lago T, Leier A, et al.
Front Big Data
. 2022 Feb;
4:727216.
PMID: 35118375
Background: Simple Sequence Repeats (SSRs) are short tandem repeats of nucleotide sequences. It has been shown that SSRs are associated with human diseases and are of medical relevance. Accordingly, a...
7.
Li F, Dong S, Leier A, Han M, Guo X, Xu J, et al.
Brief Bioinform
. 2021 Nov;
23(1).
PMID: 34729589
Conventional supervised binary classification algorithms have been widely applied to address significant research questions using biological and biomedical data. This classification scheme requires two fully labeled classes of data (e.g....
8.
Ying X, Leier A, Marquez-Lago T, Xie J, Jimeno Yepes A, Whisstock J, et al.
AMIA Annu Symp Proc
. 2021 May;
2020:1325-1334.
PMID: 33936509
Recent research in predicting protein secondary structure populations (SSP) based on Nuclear Magnetic Resonance (NMR) chemical shifts has helped quantitatively characterise the structural conformational properties of intrinsically disordered proteins and...
9.
Xu J, Li F, Leier A, Xiang D, Shen H, Marquez Lago T, et al.
Brief Bioinform
. 2021 Mar;
22(5).
PMID: 33774670
Antimicrobial peptides (AMPs) are a unique and diverse group of molecules that play a crucial role in a myriad of biological processes and cellular functions. AMP-related studies have become increasingly...
10.
Wang Y, Li F, Bharathwaj M, Rosas N, Leier A, Akutsu T, et al.
Brief Bioinform
. 2020 Nov;
22(4).
PMID: 33212503
Beta-lactamases (BLs) are enzymes localized in the periplasmic space of bacterial pathogens, where they confer resistance to beta-lactam antibiotics. Experimental identification of BLs is costly yet crucial to understand beta-lactam...