Andre Leier
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Explore the profile of Andre Leier including associated specialties, affiliations and a list of published articles.
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53
Citations
1503
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Recent Articles
11.
Nath A, Leier A
BMC Bioinformatics
. 2020 Nov;
21(1):493.
PMID: 33129275
Background: Cytokines act by binding to specific receptors in the plasma membrane of target cells. Knowledge of cytokine-receptor interaction (CRI) is very important for understanding the pathogenesis of various human...
12.
Wang J, Li J, Hou Y, Dai W, Xie R, Marquez-Lago T, et al.
Nucleic Acids Res
. 2020 Oct;
49(D1):D651-D659.
PMID: 33084862
Gram-negative bacteria utilize secretion systems to export substrates into their surrounding environment or directly into neighboring cells. These substrates are proteins that function to promote bacterial survival: by facilitating nutrient...
13.
Xie R, Li J, Wang J, Dai W, Leier A, Marquez-Lago T, et al.
Brief Bioinform
. 2020 Jun;
22(3).
PMID: 32599617
Virulence factors (VFs) enable pathogens to infect their hosts. A wealth of individual, disease-focused studies has identified a wide variety of VFs, and the growing mass of bacterial genome sequence...
14.
Chen Z, Zhao P, Li F, Leier A, Marquez-Lago T, Webb G, et al.
J Bioinform Comput Biol
. 2020 Jun;
18(4):2050018.
PMID: 32501138
Phosphorylation of histidine residues plays crucial roles in signaling pathways and cell metabolism in prokaryotes such as bacteria. While evidence has emerged that protein histidine phosphorylation also occurs in more...
15.
Jia C, Bi Y, Chen J, Leier A, Li F, Song J
Bioinformatics
. 2020 May;
36(15):4276-4282.
PMID: 32426818
Motivation: Different from traditional linear RNAs (containing 5' and 3' ends), circular RNAs (circRNAs) are a special type of RNAs that have a closed ring structure. Accumulating evidence has indicated...
16.
Li F, Leier A, Liu Q, Wang Y, Xiang D, Akutsu T, et al.
Genomics Proteomics Bioinformatics
. 2020 May;
18(1):52-64.
PMID: 32413515
Proteases are enzymes that cleave and hydrolyse the peptide bonds between two specific amino acid residues of target substrate proteins. Protease-controlled proteolysis plays a key role in the degradation and...
17.
Leier A, Bedwell D, Chen A, Dickson G, Keeling K, Kesterson R, et al.
Mol Ther Nucleic Acids
. 2020 May;
20:739-753.
PMID: 32408052
Significant advances in biotechnology have led to the development of a number of different mutation-directed therapies. Some of these techniques have matured to a level that has allowed testing in...
18.
Walton K, Leier A, Sztul E
FEBS Lett
. 2020 Apr;
594(14):2213-2226.
PMID: 32333796
Membrane traffic between secretory and endosomal compartments is vesicle-mediated and must be tightly balanced to maintain a physiological compartment size. Vesicle formation is initiated by guanine nucleotide exchange factors (GEFs)...
19.
Li F, Chen J, Leier A, Marquez-Lago T, Liu Q, Wang Y, et al.
Bioinformatics
. 2019 Oct;
36(4):1057-1065.
PMID: 31566664
Motivation: Proteases are enzymes that cleave target substrate proteins by catalyzing the hydrolysis of peptide bonds between specific amino acids. While the functional proteolysis regulated by proteases plays a central...
20.
Zhang Y, Yu S, Xie R, Li J, Leier A, Marquez-Lago T, et al.
Bioinformatics
. 2019 Aug;
36(3):704-712.
PMID: 31393553
Motivation: Gram-positive bacteria have developed secretion systems to transport proteins across their cell wall, a process that plays an important role during host infection. These secretion mechanisms have also been...