Andre G Tempone
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Explore the profile of Andre G Tempone including associated specialties, affiliations and a list of published articles.
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93
Citations
573
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Recent Articles
11.
Silva M, Sales F, Levatti E, Antar G, Tempone A, Lago J, et al.
Molecules
. 2024 Jan;
29(1).
PMID: 38202795
Endemic in 21 countries, Chagas disease, also known as American Trypanosomiasis, is a neglected tropical disease (NTD) caused by the protozoan parasite . The available drugs for the treatment of...
12.
Varela M, de Castro Levatti E, Tempone A, Fernandes J
ACS Omega
. 2023 Nov;
8(46):44265-44275.
PMID: 38027351
Melanin is a substance that plays important roles in several organisms. Its function as an antioxidant and metal-complexing agent makes tyrosinase, the key enzyme that controls melanogenesis, an interesting target...
13.
Amaral M, Asiki H, Sear C, Singh S, Pieper P, Haugland M, et al.
RSC Med Chem
. 2023 Jul;
14(7):1344-1350.
PMID: 37484568
Visceral leishmaniasis is a neglected protozoan disease with high mortality. Existing treatments exhibit a number of limitations, resulting in a significant challenge for public health, especially in developing countries in...
14.
Thevenard F, Brito I, Costa-Silva T, Tempone A, Lago J
Sci Rep
. 2023 Jun;
13(1):10254.
PMID: 37355735
Natural products are a promising source of new compounds with a wide spectrum of pharmacological properties, including antiprotozoal activities. Chagas disease, caused by the protozoan parasite Trypanosoma cruzi, is one...
15.
Londero V, Rosa M, Baitello J, Costa-Silva T, Cruz L, Tempone A, et al.
Biochim Biophys Acta Biomembr
. 2023 Jun;
1865(7):184184.
PMID: 37301246
As part of our ongoing studies involving the discovery of new natural prototypes with antiprotozoal activity against Trypanosoma cruzi from Brazilian plant species, the chromatographic fractionation of hexane extract from...
16.
Varela M, Romanelli M, Amaral M, Tempone A, Fernandes J
Saudi Pharm J
. 2023 Jun;
31(7):1265-1273.
PMID: 37287509
The absence of effective chronic treatment, expansion to non-endemic countries and the significant burden in public health have stimulated the search for novel therapeutic options to treat Chagas disease, a...
17.
Amaral M, Varela M, Kant R, Christodoulides M, Fernandes J, Tempone A
Life (Basel)
. 2023 Mar;
13(3).
PMID: 36983820
Chagas disease is an endemic tropical disease caused by the protozoan , which affects around 7 million people worldwide, mostly in development countries. The treatment relies on only two available...
18.
Leao L, de B Vieira N, Oliveira P, Chagas-Paula D, Soares M, Souza T, et al.
Bioorg Med Chem Lett
. 2023 Feb;
83:129190.
PMID: 36805048
Gibbilimbol B and analogues were isolated from the Brazilian plant Piper malacophyllum and displayed activity against trypomastigote forms of Trypanosoma cruzi as well as reduced toxicity against NCTC cells. These...
19.
de Castro Levatti E, Costa-Silva T, Morais T, Fernandes J, Lago J, Tempone A
Biochimie
. 2022 Dec;
208:141-150.
PMID: 36586562
Natural metabolites present an extraordinary chemo-diversity and have been used as the inspiration for new drugs. Considering the need for new treatments against the neglected parasitic disease leishmaniasis, three semi-synthetic...
20.
Galhardo T, Ueno A, Costa-Silva T, Tempone A, Carvalho W, Fischmeister C, et al.
Chem Biol Interact
. 2022 Sep;
366:110129.
PMID: 36067825
In the present work, dehydrodieugenol B (1) and its methyl ether (2), isolated from Nectandra leucantha twigs, were used as starting material for the preparation of two new derivatives (1a...