Andre Bensadoun
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Explore the profile of Andre Bensadoun including associated specialties, affiliations and a list of published articles.
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58
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2356
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Recent Articles
1.
He C, Hu X, Jung R, Larsson M, Tu Y, Duarte-Vogel S, et al.
JCI Insight
. 2017 Oct;
2(20).
PMID: 29046479
In mammals, GPIHBP1 is absolutely essential for transporting lipoprotein lipase (LPL) to the lumen of capillaries, where it hydrolyzes the triglycerides in triglyceride-rich lipoproteins. In all lower vertebrate species (e.g.,...
2.
Allan C, Larsson M, Jung R, Ploug M, Bensadoun A, Beigneux A, et al.
J Lipid Res
. 2016 Nov;
58(1):216-225.
PMID: 27811232
In mice lacking glycosylphosphatidylinositol-anchored high density lipoprotein binding protein 1 (GPIHBP1), the LPL secreted by adipocytes and myocytes remains bound to heparan sulfate proteoglycans (HSPGs) on all cells within tissues....
3.
Allan C, Larsson M, Hu X, He C, Jung R, Mapar A, et al.
J Lipid Res
. 2016 Aug;
57(10):1889-1898.
PMID: 27494936
LPL contains two principal domains: an amino-terminal catalytic domain (residues 1-297) and a carboxyl-terminal domain (residues 298-448) that is important for binding lipids and binding glycosylphosphatidylinositol-anchored high density lipoprotein binding...
4.
Fong L, Young S, Beigneux A, Bensadoun A, Oberer M, Jiang H, et al.
Trends Endocrinol Metab
. 2016 May;
27(7):455-469.
PMID: 27185325
GPIHBP1, a GPI-anchored protein in capillary endothelial cells, is crucial for the lipolytic processing of triglyceride-rich lipoproteins (TRLs). GPIHBP1 shuttles lipoprotein lipase (LPL) to its site of action in the...
5.
Dijk W, Beigneux A, Larsson M, Bensadoun A, Young S, Kersten S
J Lipid Res
. 2016 Apr;
57(9):1670-83.
PMID: 27034464
LPL hydrolyzes triglycerides in triglyceride-rich lipoproteins along the capillaries of heart, skeletal muscle, and adipose tissue. The activity of LPL is repressed by angiopoietin-like 4 (ANGPTL4) but the underlying mechanisms...
6.
Beigneux A, Fong L, Bensadoun A, Davies B, Oberer M, Gardsvoll H, et al.
Circ Res
. 2014 Nov;
116(4):624-32.
PMID: 25387803
Rationale: GPIHBP1, a GPI-anchored protein of capillary endothelial cells, binds lipoprotein lipase (LPL) in the subendothelial spaces and shuttles it to the capillary lumen. GPIHBP1 missense mutations that interfere with...
7.
Sha H, Sun S, Francisco A, Ehrhardt N, Xue Z, Liu L, et al.
Cell Metab
. 2014 Jul;
20(3):458-70.
PMID: 25066055
Sel1L is an essential adaptor protein for the E3 ligase Hrd1 in the endoplasmic reticulum (ER)-associated degradation (ERAD), a universal quality-control system in the cell; but its physiological role remains...
8.
Plengpanich W, Young S, Khovidhunkit W, Bensadoun A, Karnman H, Ploug M, et al.
J Biol Chem
. 2014 May;
289(28):19491-9.
PMID: 24847059
GPIHBP1, a glycosylphosphatidylinositol-anchored glycoprotein of microvascular endothelial cells, binds lipoprotein lipase (LPL) within the interstitial spaces and transports it across endothelial cells to the capillary lumen. The ability of GPIHBP1...
9.
Goulbourne C, Gin P, Tatar A, Nobumori C, Hoenger A, Jiang H, et al.
Cell Metab
. 2014 Apr;
19(5):849-60.
PMID: 24726386
Triglyceride-rich lipoproteins (TRLs) undergo lipolysis by lipoprotein lipase (LPL), an enzyme that is transported to the capillary lumen by an endothelial cell protein, GPIHBP1. For LPL-mediated lipolysis to occur, TRLs...
10.
Turlo K, Leung C, Seo J, Goulbourne C, Adeyo O, Gin P, et al.
Biochim Biophys Acta
. 2014 Apr;
1841(7):963-9.
PMID: 24704550
The S447X polymorphism in lipoprotein lipase (LPL), which shortens LPL by two amino acids, is associated with low plasma triglyceride levels and reduced risk for coronary heart disease. S447X carriers...