Anat Kreimer
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Explore the profile of Anat Kreimer including associated specialties, affiliations and a list of published articles.
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29
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861
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Recent Articles
1.
Li X, Liu J, Boreland A, Kapadia S, Zhang S, Stillitano A, et al.
Sci Adv
. 2024 Nov;
10(45):eado5820.
PMID: 39514655
Polygenic risk scores (PRSs) assess genetic susceptibility to alcohol use disorder (AUD), yet their molecular implications remain underexplored. Neuroimmune interactions, particularly in microglia, are recognized as notable contributors to AUD...
2.
Koesterich J, Liu J, Williams S, Yang N, Kreimer A
Int J Mol Sci
. 2024 Sep;
25(18).
PMID: 39337329
Gene expression is orchestrated by a complex array of gene regulatory elements that govern transcription in a cell-type-specific manner. Though previously studied, the ability to utilize regulatory elements to identify...
3.
DeGroat W, Inoue F, Ashuach T, Yosef N, Ahituv N, Kreimer A
Genome Biol
. 2024 Aug;
25(1):221.
PMID: 39143563
Background: Increasing evidence suggests that a substantial proportion of disease-associated mutations occur in enhancers, regions of non-coding DNA essential to gene regulation. Understanding the structures and mechanisms of the regulatory...
4.
DeGroat W, Inoue F, Ashuach T, Yosef N, Ahituv N, Kreimer A
bioRxiv
. 2024 Jun;
PMID: 38826254
Background: Increasing evidence suggests that a substantial proportion of disease-associated mutations occur in enhancers, regions of non-coding DNA essential to gene regulation. Understanding the structures and mechanisms of regulatory programs...
5.
Liu J, Ashuach T, Inoue F, Ahituv N, Yosef N, Kreimer A
Nucleic Acids Res
. 2024 Jan;
52(4):1613-1627.
PMID: 38296821
The advent of perturbation-based massively parallel reporter assays (MPRAs) technique has facilitated the delineation of the roles of non-coding regulatory elements in orchestrating gene expression. However, computational efforts remain scant...
6.
Liu J, Ashuach T, Inoue F, Ahituv N, Yosef N, Kreimer A
bioRxiv
. 2023 Oct;
PMID: 37808807
The advent of the perturbation-based massively parallel reporter assays (MPRAs) technique has enabled delineating of the roles of non-coding regulatory elements in orchestrating gene expression. However, computational efforts remain scant...
7.
Liu J, Kreimer A, Li W
Brief Bioinform
. 2023 Aug;
24(5).
PMID: 37598422
The advent of single-cell RNA sequencing (scRNA-seq) technologies has enabled gene expression profiling at the single-cell resolution, thereby enabling the quantification and comparison of transcriptional variability among individual cells. Although...
8.
Koesterich J, An J, Inoue F, Sohota A, Ahituv N, Sanders S, et al.
Int J Mol Sci
. 2023 Feb;
24(4).
PMID: 36834916
Autism spectrum disorder (ASD) is a common, complex, and highly heritable condition with contributions from both common and rare genetic variations. While disruptive, rare variants in protein-coding regions clearly contribute...
9.
Kreimer A, Ashuach T, Inoue F, Khodaverdian A, Deng C, Yosef N, et al.
Nat Commun
. 2022 Mar;
13(1):1504.
PMID: 35315433
Gene regulatory elements play a key role in orchestrating gene expression during cellular differentiation, but what determines their function over time remains largely unknown. Here, we perform perturbation-based massively parallel...
10.
Ziffra R, Kim C, Ross J, Wilfert A, Turner T, Haeussler M, et al.
Nature
. 2021 Oct;
598(7879):205-213.
PMID: 34616060
During mammalian development, differences in chromatin state coincide with cellular differentiation and reflect changes in the gene regulatory landscape. In the developing brain, cell fate specification and topographic identity are...