Anastassis Perrakis
Overview
Explore the profile of Anastassis Perrakis including associated specialties, affiliations and a list of published articles.
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Articles
129
Citations
6790
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Recent Articles
1.
Borza R, Matas-Rico E, Perrakis A, Moolenaar W
Trends Cell Biol
. 2025 Jan;
PMID: 39848861
Glycosylphosphatidylinositol (GPI)-anchored proteins (APs) regulate numerous biological processes through interaction with signaling effectors at the cell surface. As a unique feature, GPI-APs can be released from their anchors by multi-pass...
2.
de Vries I, Adamopoulos A, Kazokaite-Adomaitiene J, Heidebrecht T, Fish A, Celie P, et al.
J Struct Biol
. 2024 Dec;
217(1):108161.
PMID: 39674235
Base-J (β-D-glucopyranosyloxymethyluracil) is an unusual kinetoplastid-specific DNA modification, recognized by base-J containing DNA (J-DNA) binding proteins JBP1 and JBP3. Recognition of J-DNA by both JBP1 and JBP3 takes place by...
3.
Bak J, Brummelkamp T, Perrakis A
FEBS Lett
. 2024 May;
598(12):1453-1464.
PMID: 38811347
Microtubules are a major component of the cytoskeleton and can accumulate a plethora of modifications. The microtubule detyrosination cycle is one of these modifications; it involves the enzymatic removal of...
4.
Wang W, Atherton P, Kreft M, Te Molder L, van der Poel S, Hoekman L, et al.
J Cell Sci
. 2024 Apr;
137(9).
PMID: 38587458
Talin (herein referring collectively to talin 1 and 2) couples the actomyosin cytoskeleton to integrins and transmits tension to the extracellular matrix. Talin also interacts with numerous additional proteins capable...
5.
Altincekic N, Jores N, Lohr F, Richter C, Ehrhardt C, Blommers M, et al.
ACS Chem Biol
. 2024 Jan;
19(2):563-574.
PMID: 38232960
The main protease M, nsp5, of SARS-CoV-2 (SCoV2) is one of its most attractive drug targets. Here, we report primary screening data using nuclear magnetic resonance spectroscopy (NMR) of four...
6.
Bai X, Gonen T, Gronenborn A, Perrakis A, Thorn A, Yang J
Nat Rev Mol Cell Biol
. 2023 Oct;
25(1):7-12.
PMID: 37848590
No abstract available.
7.
de Vries I, Ammerlaan D, Heidebrecht T, Celie P, Geerke D, Joosten R, et al.
Life Sci Alliance
. 2023 Jun;
6(9).
PMID: 37328191
Base-J (β-D-glucopyranosyloxymethyluracil) is a modified DNA nucleotide that replaces 1% of thymine in kinetoplastid flagellates. The biosynthesis and maintenance of base-J depends on the base-J-binding protein 1 (JBP1) that has...
8.
Agirre J, Atanasova M, Bagdonas H, Ballard C, Basle A, Beilsten-Edmands J, et al.
Acta Crystallogr D Struct Biol
. 2023 Jun;
79(Pt 6):449-461.
PMID: 37259835
The Collaborative Computational Project No. 4 (CCP4) is a UK-led international collective with a mission to develop, test, distribute and promote software for macromolecular crystallography. The CCP4 suite is a...
9.
Bak J, Landskron L, Brummelkamp T, Perrakis A
J Vis Exp
. 2023 Mar;
(193).
PMID: 36939268
Microtubules are an important part of the cytoskeleton and are involved in intracellular organization, cell division, and migration. Depending on the posttranslational modifications, microtubules can form complexes with various interacting...
10.
Salgado-Polo F, Borza R, Matsoukas M, Marsais F, Jagerschmidt C, Waeckel L, et al.
Cell Chem Biol
. 2023 Jan;
30(1):69-84.e14.
PMID: 36640760
Autotaxin (ATX; ENPP2) produces the lipid mediator lysophosphatidic acid (LPA) that signals through disparate EDG (LPA) and P2Y (LPA) G protein-coupled receptors. ATX/LPA promotes several (patho)physiological processes, including in pulmonary...