Anant K Menon
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Explore the profile of Anant K Menon including associated specialties, affiliations and a list of published articles.
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2728
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Recent Articles
11.
Morra G, Razavi A, Menon A, Khelashvili G
Structure
. 2022 Jun;
30(8):1208-1217.e2.
PMID: 35660161
Class A (rhodopsin-like) G protein-coupled receptors (GPCRs) are constitutive phospholipid scramblases as evinced after their reconstitution into liposomes. Yet phospholipid scrambling is not detectable in the resting plasma membrane of...
12.
Wang Y, Menon A, Maki Y, Liu Y, Iwasaki Y, Fujita M, et al.
Proc Natl Acad Sci U S A
. 2022 Mar;
119(14):e2115083119.
PMID: 35344438
SignificanceScramblases translocate lipids across the lipid bilayer without consumption of ATP, thereby regulating lipid distributions in cellular membranes. Cytosol-to-lumen translocation across the endoplasmic reticulum (ER) membrane is a common process...
13.
Feuda R, Menon A, Gopfert M
Mol Biol Evol
. 2022 Feb;
39(3).
PMID: 35143663
Opsins, the protein moieties of animal visual photo-pigments, have emerged as moonlighting proteins with diverse, light-dependent and -independent physiological functions. This raises the need to revise some basic assumptions concerning...
14.
Khelashvili G, Menon A
Annu Rev Biophys
. 2021 Dec;
51:39-61.
PMID: 34932914
Rapid flip-flop of phospholipids across the two leaflets of biological membranes is crucial for many aspects of cellular life. The transport proteins that facilitate this process are classified as pump-like...
15.
Cowton A, Butikofer P, Haner R, Menon A
Mol Microbiol
. 2021 Dec;
117(2):450-461.
PMID: 34875117
Glycosylphosphatidylinositol (GPI)-anchored proteins are found in all eukaryotes and are especially abundant on the surface of protozoan parasites such as Trypanosoma brucei. GPI-mannosyltransferase-I (GPI-MT-I) catalyzes the addition of the first...
16.
Jenni A, Knusel S, Nagar R, Benninger M, Haner R, Ferguson M, et al.
J Biol Chem
. 2021 Jul;
297(2):100977.
PMID: 34284059
Many eukaryotic cell-surface proteins are post-translationally modified by a glycosylphosphatidylinositol (GPI) moiety that anchors them to the cell membrane. The biosynthesis of GPI anchors is initiated in the endoplasmic reticulum...
17.
Mathiassen P, Menon A, Pomorski T
Sci Rep
. 2021 Jul;
11(1):14364.
PMID: 34257324
Transbilayer movement of phospholipids in biological membranes is mediated by a diverse set of lipid transporters. Among them are scramblases that facilitate a rapid bi-directional movement of lipids without metabolic...
18.
Khelashvili G, Narayana Pillai A, Lee J, Pandey K, Payne A, Siegel Z, et al.
Sci Rep
. 2021 May;
11(1):10536.
PMID: 34006992
Mutations in the G protein-coupled receptor (GPCR) rhodopsin are a common cause of autosomal dominant retinitis pigmentosa, a blinding disease. Rhodopsin self-associates in the membrane, and the purified monomeric apo-protein...
19.
Verchere A, Cowton A, Jenni A, Rauch M, Haner R, Graumann J, et al.
Sci Rep
. 2021 Jan;
11(1):1411.
PMID: 33446867
The oligosaccharide required for asparagine (N)-linked glycosylation of proteins in the endoplasmic reticulum (ER) is donated by the glycolipid GlcManGlcNAc-PP-dolichol. Remarkably, whereas glycosylation occurs in the ER lumen, the initial...
20.
Picca G, Probst M, Langenegger S, Khorev O, Butikofer P, Menon A, et al.
Beilstein J Org Chem
. 2020 Aug;
16:1732-1739.
PMID: 32765793
The chemical synthesis of molecular probes to identify and study membrane proteins involved in the biological pathway of protein glycosylation is described. Two short-chain glycolipid analogs that mimic the naturally...