Ana S Newton
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Explore the profile of Ana S Newton including associated specialties, affiliations and a list of published articles.
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15
Citations
108
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Recent Articles
11.
Carrasco M, Newton A, Goncalves L, Gois A, Machado M, Gut J, et al.
Eur J Med Chem
. 2014 May;
80:523-34.
PMID: 24813880
A library comprising 44 diversely substituted aurones derivatives was synthesized by straightforward aldol condensation reactions of benzofuranones and the appropriately substituted benzaldehydes. Microwave enhanced synthesis using palladium catalyzed protocols was...
12.
Mugumbate G, Newton A, Rosenthal P, Gut J, Moreira R, Chibale K, et al.
J Comput Aided Mol Des
. 2013 Oct;
27(10):859-71.
PMID: 24158745
Increased resistance of Plasmodium falciparum to most available drugs challenges the control of malaria. Studies with protease inhibitors have suggested important roles for the falcipain family of cysteine proteases. These...
13.
Oliveira R, Newton A, Guedes R, Miranda D, Amewu R, Srivastava A, et al.
ChemMedChem
. 2013 Jul;
8(9):1528-36.
PMID: 23853126
The emergence of artemisinin-resistant Plasmodium falciparum malaria in Southeast Asia has reinforced the urgent need to discover novel chemotherapeutic strategies to treat and control malaria. To address this problem, we...
14.
Gloria P, Coutinho I, Goncalves L, Baptista C, Soares J, Newton A, et al.
Eur J Med Chem
. 2011 Mar;
46(6):2141-6.
PMID: 21439692
In this article we describe an expanded structure-activity relationship study for vinyl sulfones as caspase-3 inhibitors, a topic virtually unexplored in the existing literature. Most remarkably, and to our surprise,...
15.
Newton A, Gloria P, Goncalves L, Dos Santos D, Moreira R, Guedes R, et al.
Eur J Med Chem
. 2010 Jun;
45(9):3858-63.
PMID: 20541849
The first structure-activity relationship study of vinyl sulfones as caspase-3 inhibitors is reported. A series of 12 vinyl sulfones was synthesized and evaluated for two downstream caspases (caspases-3 and -7)....