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Ana Olivera

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Articles 77
Citations 3048
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Recent Articles
1.
Luker A, Wukitch A, Kulinski J, Ganesan S, Kabat J, Lack J, et al.
Front Immunol . 2024 Aug; 15:1427509. PMID: 39188715
The successful development of germinal centers (GC) relies heavily on innate mechanisms to amplify the initial inflammatory cascade. In addition to their role in antigen presentation, innate cells are essential...
2.
Yin Y, Li J, Metcalfe D, Olivera A, Frischmeyer-Guerrerio P, Carter M, et al.
J Allergy Clin Immunol Glob . 2024 Aug; 3(4):100296. PMID: 39148513
Background: Symptoms in patients with systemic mastocytosis (SM) are associated with an increase in mast cell burden and release of mast cell-derived mediators. The most frequent presentation of SM is...
3.
Trzaskoma P, Jung S, Pekowska A, Bohrer C, Wang X, Naz F, et al.
Sci Adv . 2024 Aug; 10(32):eadl4893. PMID: 39121214
Discontinuous transcription is evolutionarily conserved and a fundamental feature of gene regulation; yet, the exact mechanisms underlying transcriptional bursting are unresolved. Analyses of bursting transcriptome-wide have focused on the role...
4.
Pfeiffer A, Bandara G, Petersen J, Falduto G, Zimmerberg J, Metcalfe D, et al.
J Extracell Biol . 2024 Jun; 3(1):e139. PMID: 38938682
The receptor tyrosine kinase (RTK) KIT and its ligand stem cell factor (SCF) are essential for human mast cell (huMC) survival and proliferation. HuMCs expressing oncogenic KIT variants secrete large...
5.
Bandara G, Falduto G, Luker A, Bai Y, Pfeiffer A, Lack J, et al.
Front Immunol . 2023 Apr; 14:1078958. PMID: 37025992
The HMC-1.2 human mast cell (huMC) line is often employed in the study of attributes of neoplastic huMCs as found in patients with mastocytosis and their sensitivity to interventional drugs...
6.
Dispenza M, Metcalfe D, Olivera A
J Allergy Clin Immunol Pract . 2023 Mar; 11(7):2032-2042. PMID: 36958519
Anaphylaxis is an acute, potentially life-threatening systemic allergic reaction for which there are no known reliable preventative therapies. Its primary cell mediator, the mast cell, has several pathophysiologic roles and...
7.
Pfeiffer A, Petersen J, Falduto G, Anderson D, Zimmerberg J, Metcalfe D, et al.
J Extracell Vesicles . 2022 Oct; 11(10):e12272. PMID: 36239715
Activating mutations in the receptor KIT promote the dysregulated proliferation of human mast cells (huMCs). The resulting neoplastic huMCs secrete extracellular vesicles (EVs) that can transfer oncogenic KIT among other...
8.
Zhao Y, Vartak S, Conte A, Wang X, Garcia D, Stevens E, et al.
Mol Cell . 2022 Jul; 82(18):3398-3411.e11. PMID: 35863348
Regulatory elements activate promoters by recruiting transcription factors (TFs) to specific motifs. Notably, TF-DNA interactions often depend on cooperativity with colocalized partners, suggesting an underlying cis-regulatory syntax. To explore TF...
9.
Falduto G, Pfeiffer A, Zhang Q, Yin Y, Metcalfe D, Olivera A
Front Immunol . 2022 Mar; 13:841045. PMID: 35251038
Mast cell hyperactivity and accumulation in tissues are associated with allergy and other mast cell-related disorders. However, the molecular pathways regulating mast cell survival in homeostasis and disease are not...
10.
Navines-Ferrer A, Ainsua-Enrich E, Serrano-Candelas E, Proano-Perez E, Munoz-Cano R, Gastaminza G, et al.
J Immunol . 2021 Oct; 207(11):2894. PMID: 34716186
No abstract available.