Alasdair M Gilfillan
Overview
Explore the profile of Alasdair M Gilfillan including associated specialties, affiliations and a list of published articles.
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71
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3153
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Recent Articles
1.
Desai A, Jung M, Olivera A, Gilfillan A, Prussin C, Kirshenbaum A, et al.
J Allergy Clin Immunol
. 2016 Jan;
137(6):1863-1871.e6.
PMID: 26774658
Background: IL-6, levels of which are reported to be increased in association with mastocytosis, asthma, and urticaria, is used in conjunction with stem cell factor to generate CD34(+) cell-derived primary...
2.
Bandara G, Beaven M, Olivera A, Gilfillan A, Metcalfe D
Eur J Immunol
. 2015 Aug;
45(11):3034-44.
PMID: 26256265
IL-33 released from damaged cells plays a central role in allergic inflammation by acting through its membrane-bound receptor, ST2 receptor (ST2L). IL-33 activity can be neutralized by the soluble spliced...
3.
Cruse G, Beaven M, Music S, Bradding P, Gilfillan A, Metcalfe D
Mol Biol Cell
. 2015 Feb;
26(9):1711-27.
PMID: 25717186
MS4A family members differentially regulate the cell cycle, and aberrant, or loss of, expression of MS4A family proteins has been observed in colon and lung cancer. However, the precise functions...
4.
Hox V, Desai A, Bandara G, Gilfillan A, Metcalfe D, Olivera A
J Allergy Clin Immunol
. 2015 Jan;
135(3):729-36.e5.
PMID: 25553642
Background: Clinical observations suggest that anaphylaxis is more common in adult women compared with adult men, although the mechanistic basis for this sex bias is not well understood. Objectives: We...
5.
Cruse G, Gilfillan A, Smrz D
Methods Mol Biol
. 2014 Nov;
1220:365-79.
PMID: 25388263
Mast cell activation is a central process in the initiation of allergic disorders. As described elsewhere in this volume, this process can be readily monitored by biochemical, antibody-based, and enzyme-based...
6.
Radinger M, Jensen B, Swindle E, Gilfillan A
Methods Mol Biol
. 2014 Nov;
1220:307-23.
PMID: 25388259
Mediator release from activated mast cells is a major initiator of the symptomology associated with allergic disorders such as anaphylaxis and asthma. Thus, methods to monitor the generation and release...
7.
Smrz D, Cruse G, Beaven M, Kirshenbaum A, Metcalfe D, Gilfillan A
J Immunol
. 2014 Nov;
193(12):5924-32.
PMID: 25378594
Rictor is a regulatory component of the mammalian target of rapamycin (mTOR) complex 2 (mTORC2). We have previously demonstrated that rictor expression is substantially downregulated in terminally differentiated mast cells...
8.
Chan E, Bai Y, Kirshenbaum A, Fischer E, Simakova O, Bandara G, et al.
J Allergy Clin Immunol
. 2014 Mar;
134(1):178-87.
PMID: 24582309
Background: Mastocytosis associated with germline KIT activating mutations is exceedingly rare. We report the unique clinicopathologic features of a patient with systemic mastocytosis caused by a de novo germline KIT...
9.
Siegel A, Stone K, Cruse G, Lawrence M, Olivera A, Jung M, et al.
J Allergy Clin Immunol
. 2013 Nov;
132(6):1388-96.
PMID: 24184145
Background: Severe atopic conditions associated with elevated serum IgE are heterogeneous with few known causes. Nearly every patient with autosomal-dominant hyper-IgE syndrome (AD-HIES) due to signal transducer and activator of...
10.
Chan E, Bai Y, Bandara G, Simakova O, Brittain E, Scott L, et al.
Exp Hematol
. 2013 Jun;
41(10):870-881.e2.
PMID: 23743299
Stem cell factor-dependent KIT activation is an essential process for mast cell homeostasis. The two major splice variants of KIT differ by the presence or absence of four amino acids...