Ana M Sebastiao
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Explore the profile of Ana M Sebastiao including associated specialties, affiliations and a list of published articles.
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153
Citations
2676
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Recent Articles
11.
Soares R, Lourenco D, Mota I, Sebastiao A, Xapelli S, Morais V
Life Sci Alliance
. 2024 Apr;
7(7).
PMID: 38664022
Neural stem cells (NSCs) reside in discrete regions of the adult mammalian brain where they can differentiate into neurons, astrocytes, and oligodendrocytes. Several studies suggest that mitochondria have a major...
12.
Goncalves-Ribeiro J, Savchak O, Costa-Pinto S, Gomes J, Rivas-Santisteban R, Lillo A, et al.
Glia
. 2024 Mar;
72(6):1096-1116.
PMID: 38482984
The medial prefrontal cortex (mPFC) is involved in cognitive functions such as working memory. Astrocytic cannabinoid type 1 receptor (CB1R) induces cytosolic calcium (Ca) concentration changes with an impact on...
13.
Farinha-Ferreira M, Magalhaes D, Neuparth-Sottomayor M, Rafael H, Miranda-Lourenco C, Sebastiao A
J Neurochem
. 2024 Mar;
168(9):2443-2460.
PMID: 38430009
Reductionistic research on depressive disorders has been hampered by the limitations of animal models. Recently, it has been hypothesized that neuroinflammation is a key player in depressive disorders. The Wistar-Kyoto...
14.
Magalhaes D, Stewart N, Mampay M, Rolle S, Hall C, Moeendarbary E, et al.
J Neurochem
. 2024 Feb;
168(6):1113-1142.
PMID: 38339785
The small-molecule drug, FTY720 (fingolimod), is a synthetic sphingosine 1-phosphate (S1P) analogue currently used to treat relapsing-remitting multiple sclerosis in both adults and children. FTY720 can cross the blood-brain barrier...
15.
Costa-Pinto S, Goncalves-Ribeiro J, Tedim-Moreira J, Socodato R, Relvas J, Sebastiao A, et al.
Neurobiol Dis
. 2024 Feb;
193:106435.
PMID: 38336279
Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease, involving the selective degeneration of cortical upper synapses in the primary motor cortex (M1). Excitotoxicity in ALS occurs due to an imbalance...
16.
Magalhaes D, Mampay M, Sebastiao A, Sheridan G, Valente C
Neurochem Int
. 2024 Jan;
174:105678.
PMID: 38266657
Social isolation is a chronic mild stressor and a significant risk factor for mental health disorders. Herein we explored the impact of social isolation on depression- and anxiety-like behaviours, as...
17.
Abreu D, Gomes J, Ribeiro F, Diogenes M, Sebastiao A, Vaz S
Front Cell Neurosci
. 2023 Dec;
17:1282841.
PMID: 38145284
Astrocytes, the most abundant glial cells in the central nervous system (CNS), sense synaptic activity and respond through the release of gliotransmitters, a process mediated by intracellular Ca level changes...
18.
Miranda-Lourenco C, Rosa J, Rei N, Belo R, Lopes A, Silva D, et al.
Int J Mol Sci
. 2023 Nov;
24(22).
PMID: 38003438
Rett Syndrome is an X-linked neurodevelopmental disorder (RTT; OMIM#312750) associated to mutations. MeCP2 dysfunction is seen as one cause for the deficiencies found in brain-derived neurotrophic factor (BDNF) signaling, since...
19.
Lourenco D, Soares R, Sa-Santos S, Mateus J, Rodrigues R, Moreira J, et al.
Eur J Pharmacol
. 2023 Oct;
959:176079.
PMID: 37802277
Postnatal neurogenesis has been shown to rely on the endocannabinoid system. Here we aimed at unravelling the role of Cannabidivarin (CBDV), a non-psychoactive cannabinoid, with high affinity for the non-classical...
20.
Adjusting the brakes to adjust neuronal activity: Adenosinergic modulation of GABAergic transmission
Sebastiao A, Ribeiro J
Neuropharmacology
. 2023 May;
236:109600.
PMID: 37225084
About 50 years elapsed from the publication of the first full paper on the neuromodulatory action of adenosine at a 'simple' synapse model, the neuromuscular junction (Ginsborg and Hirst, 1972)....