Claudia A Valente
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Explore the profile of Claudia A Valente including associated specialties, affiliations and a list of published articles.
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18
Citations
343
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Recent Articles
1.
Gonzalez-Ramos A, Berglind F, Kudlacek J, Rocha E, Melin E, Sebastiao A, et al.
Gene Ther
. 2024 Oct;
PMID: 39455855
Despite the availability of new drugs on the clinics in recent years, drug-resistant epilepsy remains an unresolved challenge for healthcare, and one-third of epilepsy patients remain refractory to anti-seizure medications....
2.
Ghosh A, Ribeiro-Rodrigues L, Ruffolo G, Alfano V, Domingos C, Rei N, et al.
Br J Pharmacol
. 2024 Sep;
181(24):5041-5061.
PMID: 39300608
Background And Purpose: Adenosine, through the A receptor (AR), is an endogenous anticonvulsant. The development of adenosine receptor agonists as antiseizure medications has been hampered by their cardiac side effects....
3.
Magalhaes D, Stewart N, Mampay M, Rolle S, Hall C, Moeendarbary E, et al.
J Neurochem
. 2024 Feb;
168(6):1113-1142.
PMID: 38339785
The small-molecule drug, FTY720 (fingolimod), is a synthetic sphingosine 1-phosphate (S1P) analogue currently used to treat relapsing-remitting multiple sclerosis in both adults and children. FTY720 can cross the blood-brain barrier...
4.
Magalhaes D, Mampay M, Sebastiao A, Sheridan G, Valente C
Neurochem Int
. 2024 Jan;
174:105678.
PMID: 38266657
Social isolation is a chronic mild stressor and a significant risk factor for mental health disorders. Herein we explored the impact of social isolation on depression- and anxiety-like behaviours, as...
5.
Rei N, Valente C, Vaz S, Farinha-Ferreira M, Ribeiro J, Sebastiao A
PLoS One
. 2022 Dec;
17(12):e0272104.
PMID: 36516126
Amyotrophic lateral sclerosis (ALS) is characterized by the progressive degeneration of corticospinal tract motor neurons. Previous studies showed that adenosine-mediated neuromodulation is disturbed in ALS and that vascular endothelial growth...
6.
Van Zeller M, Sebastiao A, Valente C
Biomolecules
. 2022 May;
12(5).
PMID: 35625594
Astrocytes are the most abundant cells in the CNS parenchyma and play an essential role in several brain functions, such as the fine-tuning of synaptic transmission, glutamate uptake and the...
7.
Murtinheira F, Migueis M, Letra-Vilela R, Diallo M, Quezada A, Valente C, et al.
Cells
. 2022 Jan;
11(2).
PMID: 35053415
Autosomal recessive spastic ataxia of Charlevoix-Saguenay (ARSACS) is a neurodegenerative disorder commonly diagnosed in infants and characterized by progressive cerebellar ataxia, spasticity, motor sensory neuropathy and axonal demyelination. ARSACS is...
8.
Van Zeller M, Dias D, Sebastiao A, Valente C
J Alzheimers Dis
. 2021 Aug;
83(3):939-961.
PMID: 34366341
Alzheimer's disease (AD) is the most prevalent neurodegenerative disease commonly diagnosed among the elderly population. AD is characterized by the loss of synaptic connections, neuronal death, and progressive cognitive impairment,...
9.
Valente C, Meda F, Carvalho M, Sebastiao A
J Vis Exp
. 2021 Apr;
(169).
PMID: 33818560
Organotypic slice cultures have been widely used to model brain disorders and are considered excellent platforms for evaluating a drug's neuroprotective and therapeutic potential. Organotypic slices are prepared from explanted...
10.
Belo R, F Martins M, Shvachiy L, Costa-Coelho T, de Almeida-Borlido C, Fonseca-Gomes J, et al.
Front Pharmacol
. 2020 Aug;
11:985.
PMID: 32733240
Kyotorphin (KTP, l-tyrosyl-l-arginine) is an endogenous dipeptide initially described to have analgesic properties. Recently, KTP was suggested to be an endogenous neuroprotective agent, namely for Alzheimer's disease (AD). In fact,...