Ana M Diaz Espinosa
Overview
Explore the profile of Ana M Diaz Espinosa including associated specialties, affiliations and a list of published articles.
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6
Citations
157
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Recent Articles
1.
Gao A, Diaz Espinosa A, Nguyen B, Link P, Meridew J, Jones D, et al.
J Pharmacol Exp Ther
. 2023 Apr;
386(3):277-287.
PMID: 37024146
Pulmonary fibroblasts are the primary producers of extracellular matrix (ECM) in the lungs, and their pathogenic activation drives scarring and loss of lung function in idiopathic pulmonary fibrosis (IPF). This...
2.
Gao A, Diaz Espinosa A, Giani F, Pham T, Carver C, Aravamudhan A, et al.
Am J Physiol Lung Cell Mol Physiol
. 2022 Oct;
323(6):L685-L697.
PMID: 36223640
Cellular senescence is emerging as a driver of idiopathic pulmonary fibrosis (IPF), a progressive and fatal disease with limited effective therapies. The senescence-associated secretory phenotype (SASP), involving the release of...
3.
Link P, Choi K, Diaz Espinosa A, Jones D, Gao A, Haak A, et al.
Am J Physiol Lung Cell Mol Physiol
. 2021 Nov;
322(1):L23-L32.
PMID: 34755530
Yes-associated protein (YAP) and transcriptional coactivator with PDZ-binding motif (TAZ) are transcription cofactors implicated in the contractile and profibrotic activation of fibroblasts. Fibroblast contractile function is important in alveologenesis and...
4.
Choi K, Haak A, Diaz Espinosa A, Cummins K, Link P, Aravamudhan A, et al.
J Cell Physiol
. 2021 May;
236(11):7759-7774.
PMID: 34046891
Yes-associated protein (YAP) and PDZ-binding motif (TAZ) have emerged as important regulators of pathologic fibroblast activation in fibrotic diseases. Agonism of Gαs-coupled G protein coupled receptors (GPCRs) provides an attractive...
5.
Haak A, Ducharme M, Diaz Espinosa A, Tschumperlin D
Trends Pharmacol Sci
. 2020 Feb;
41(3):172-182.
PMID: 32008852
A variety of G protein-coupled receptors (GPCRs) have been implicated in the pathogenesis of pulmonary fibrosis, largely through their promotion of profibrotic fibroblast activation. By contrast, recent work has highlighted...
6.
Haak A, Kostallari E, Sicard D, Ligresti G, Choi K, Caporarello N, et al.
Sci Transl Med
. 2019 Nov;
11(516).
PMID: 31666402
Tissue fibrosis is characterized by uncontrolled deposition and diminished clearance of fibrous connective tissue proteins, ultimately leading to organ scarring. Yes-associated protein (YAP) and transcriptional coactivator with PDZ-binding motif (TAZ)...