Daniel J Tschumperlin
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Explore the profile of Daniel J Tschumperlin including associated specialties, affiliations and a list of published articles.
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Articles
117
Citations
5792
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Recent Articles
1.
Neblett 2nd M, Ducharme M, Meridew J, Haak A, Girard S, Tschumperlin D, et al.
Reprod Sci
. 2024 Dec;
32(2):417-427.
PMID: 39738934
Uterine leiomyomas are common noncancerous hormonally-dependent neoplasms comprised of uterine smooth-muscle cells and fibroblasts. Despite their significant impact on morbidity, effective non-hormonal medical treatments are lacking. In vitro studies have...
2.
Magdaleno C, Tschumperlin D, Rajasekaran N, Varadaraj A
Sci Rep
. 2024 Dec;
14(1):31855.
PMID: 39738247
Idiopathic pulmonary fibrosis (IPF) is a fatal disease defined by a progressive decline in lung function due to scarring and accumulation of extracellular matrix (ECM) proteins. The SOCS (Suppressor Of...
3.
Samson S, Rojas A, Zitnay R, Carney K, Hettinga W, Schaelling M, et al.
bioRxiv
. 2024 Sep;
PMID: 39345541
Pre-cancerous lung lesions are commonly initiated by activating mutations in the RAS pathway, but do not transition to lung adenocarcinomas (LUAD) without additional oncogenic signals. Here, we show that expression...
4.
Tan Q, Wellmerling J, Song S, Dresler S, Meridew J, Choi K, et al.
JCI Insight
. 2024 Jul;
9(16).
PMID: 39012710
Fibrosis in the lung is thought to be driven by epithelial cell dysfunction and aberrant cell-cell interactions. Unveiling the molecular mechanisms of cellular plasticity and cell-cell interactions is imperative to...
5.
Wellmerling J, Dresler S, Meridew J, Choi K, Tschumperlin D, Tan Q
Physiol Rep
. 2024 Jul;
12(13):e16148.
PMID: 38991987
Pulmonary fibrosis is characterized by pathological accumulation of scar tissue in the lung parenchyma. Many of the processes that are implicated in fibrosis, including increased extracellular matrix synthesis, also occur...
6.
Link P, Meridew J, Caporarello N, Gao A, Peters V, Rojas M, et al.
Am J Respir Cell Mol Biol
. 2024 Jul;
71(6):718-729.
PMID: 38959411
Idiopathic pulmonary fibrosis (IPF) is an aggressive and, thus far, incurable disease characterized by aberrant fibroblast-mediated extracellular matrix deposition. Our understanding of the disease etiology is incomplete; however, there is...
7.
Hynds R, Magin C, Ikonomou L, Aschner Y, Beers M, Burgess J, et al.
Am J Physiol Lung Cell Mol Physiol
. 2024 May;
327(3):L327-L340.
PMID: 38772903
Repair and regeneration of a diseased lung using stem cells or bioengineered tissues is an exciting therapeutic approach for a variety of lung diseases and critical illnesses. Over the past...
8.
Aravamudhan A, Dieffenbach P, Choi K, Link P, Meridew J, Haak A, et al.
Physiol Rep
. 2024 Apr;
12(7):e15999.
PMID: 38610069
Pulmonary arterial hypertension (PAH) causes pulmonary vascular remodeling, increasing pulmonary vascular resistance (PVR) and leading to right heart failure and death. Matrix stiffening early in the disease promotes remodeling in...
9.
Magdaleno C, Tschumperlin D, Rajasekaran N, Varadaraj A
bioRxiv
. 2024 Mar;
PMID: 38469152
Idiopathic pulmonary fibrosis (IPF) is a fatal disease defined by a progressive decline in lung function due to scarring and accumulation of extracellular matrix (ECM) proteins. The SOCS (Suppressor Of...
10.
Arnold K, Weaver S, Zars E, Tschumperlin D, Westendorf J
Osteoarthritis Cartilage
. 2024 Mar;
32(6):680-689.
PMID: 38432607
Objective: Phlpp1 inhibition is a potential therapeutic strategy for cartilage regeneration and prevention of post-traumatic osteoarthritis (PTOA). To understand how Phlpp1 loss affects cartilage structure, cartilage elastic modulus was measured...