Ana J Garcia-Saez
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Explore the profile of Ana J Garcia-Saez including associated specialties, affiliations and a list of published articles.
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125
Citations
6280
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Recent Articles
1.
Smarduch S, Moreno-Velasquez S, Ilic D, Dadsena S, Morant R, Ciprinidis A, et al.
EMBO J
. 2025 Feb;
PMID: 39984755
The cGAS-STING signalling pathway has a central role in the innate immune response to extrinsic and intrinsic sources of cytoplasmic dsDNA. At the core of this pathway is cGAS-dependent production...
2.
Pedrera L, Prieto Clemente L, Dahlhaus A, Lotfipour Nasudivar S, Tishina S, Olmo Gonzalez D, et al.
Cell Death Dis
. 2025 Jan;
16(1):40.
PMID: 39863602
Constitutive mitochondrial dynamics ensure quality control and metabolic fitness of cells, and their dysregulation has been implicated in various human diseases. The large GTPase Dynamin-related protein 1 (Drp1) is intimately...
3.
Etxebeste-Mitxeltorena M, Flores-Romero H, Ramos-Inza S, Masia E, Nenchova M, Montesinos J, et al.
J Med Chem
. 2025 Jan;
68(2):1179-1194.
PMID: 39778888
Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease without effective treatment. The progressive motoneuron death in ALS is associated with alterations in lipid metabolism. As its regulation occurs in...
4.
Schmitt L, Krings K, Wolsing A, Buque X, Zimmermann M, Flores-Romero H, et al.
Cell Commun Signal
. 2024 Nov;
22(1):541.
PMID: 39533399
Targeting mitochondrial metabolism represents a promising approach for cancer treatment. Here, we investigated the mitotoxic potential of the polybrominated diphenyl ether bromoxib, a natural compound isolated from the marine sponge...
5.
Lotfipour Nasudivar S, Pedrera L, Garcia-Saez A
Langmuir
. 2024 Nov;
40(47):25061-25068.
PMID: 39532309
Ferroptosis is a form of regulated necrosis characterized by the iron-dependent accumulation of lipid peroxides in cell membranes. However, how lipid oxidation via iron-mediated Fenton reactions affects the biophysical properties...
6.
Dellmann T, Shalaby R, Garcia-Saez A
Methods Enzymol
. 2024 Jul;
700:161-187.
PMID: 38971599
No abstract available.
7.
Berndt C, Alborzinia H, Amen V, Ayton S, Barayeu U, Bartelt A, et al.
Redox Biol
. 2024 Jun;
75:103211.
PMID: 38908072
Ferroptosis is a pervasive non-apoptotic form of cell death highly relevant in various degenerative diseases and malignancies. The hallmark of ferroptosis is uncontrolled and overwhelming peroxidation of polyunsaturated fatty acids...
8.
Jenner A, Garcia-Saez A
Adv Immunol
. 2024 Jun;
162:59-108.
PMID: 38866439
Apoptotic pore formation in mitochondria is the pivotal point for cell death during mitochondrial apoptosis. It is regulated by BCL-2 family proteins in response to various cellular stress triggers and...
9.
Dadsena S, Cuevas Arenas R, Vieira G, Brodesser S, Melo M, Garcia-Saez A
Nat Commun
. 2024 Jun;
15(1):4700.
PMID: 38830851
BAX and BAK are proapoptotic members of the BCL2 family that directly mediate mitochondrial outer membrane permeabilition (MOMP), a central step in apoptosis execution. However, the molecular architecture of the...
10.
Froehlich T, Jenner A, Cavarischia-Rega C, Fagbadebo F, Lurz Y, Frecot D, et al.
Life Sci Alliance
. 2024 May;
7(8).
PMID: 38816213
In cells, mitochondria undergo constant fusion and fission. An essential factor for fission is the mammalian dynamin-related protein 1 (Drp1). Dysregulation of Drp1 is associated with neurodegenerative diseases including Parkinson's,...