Ana Galan-Cobo
Overview
Explore the profile of Ana Galan-Cobo including associated specialties, affiliations and a list of published articles.
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12
Citations
1164
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Recent Articles
1.
MCT4-dependent lactate secretion suppresses antitumor immunity in LKB1-deficient lung adenocarcinoma
Qian Y, Galan-Cobo A, Guijarro I, Dang M, Molkentine D, Poteete A, et al.
Cancer Cell
. 2023 Jun;
41(7):1363-1380.e7.
PMID: 37327788
Inactivating STK11/LKB1 mutations are genomic drivers of primary resistance to immunotherapy in KRAS-mutated lung adenocarcinoma (LUAD), although the underlying mechanisms remain unelucidated. We find that LKB1 loss results in enhanced...
2.
Galan-Cobo A, Stellrecht C, Yilmaz E, Yang C, Qian Y, Qu X, et al.
Mol Cancer Res
. 2021 Oct;
20(2):280-292.
PMID: 34654720
Loss-of-function somatic mutations of , a tumor suppressor gene encoding LKB1 that contributes to the altered metabolic phenotype of cancer cells, is the second most common event in lung adenocarcinomas...
3.
Sitthideatphaiboon P, Galan-Cobo A, Negrao M, Qu X, Poteete A, Zhang F, et al.
Clin Cancer Res
. 2020 Dec;
27(6):1720-1733.
PMID: 33323404
Purpose: Radiotherapy with or without chemotherapy is a mainstay of treatment for locally advanced non-small cell lung cancer (NSCLC), but no predictive markers are currently available to select patients who...
4.
Galan-Cobo A, Sitthideatphaiboon P, Qu X, Poteete A, Pisegna M, Tong P, et al.
Cancer Res
. 2019 May;
79(13):3251-3267.
PMID: 31040157
In -mutant lung adenocarcinoma, tumors with LKB1 loss (KL) are highly enriched for concurrent mutations, which activate the KEAP1/NRF2 pathway (KLK). Here, we investigated the biological consequences of these cooccurring...
5.
Trillo-Contreras J, Ramirez-Lorca R, Hiraldo-Gonzalez L, Sanchez-Gomar I, Galan-Cobo A, Suarez-Luna N, et al.
Biochim Biophys Acta Mol Basis Dis
. 2018 Oct;
1864(10):3515-3526.
PMID: 30293570
Aquaporin-4, present in ependymal cells, in glia limiting and abundantly in pericapillary astrocyte foot processes, and aquaporin-1, expressed in choroid plexus epithelial cells, play an important role in cerebrospinal fluid...
6.
Galan-Cobo A, Arellano-Orden E, Sanchez Silva R, Lopez-Campos J, Gutierrez Rivera C, Gomez Izquierdo L, et al.
Front Mol Biosci
. 2018 May;
5:43.
PMID: 29774214
Activation of the epithelial-mesenchymal transition process (EMT) by which alveolar cells in human lung tissue undergo differentiation giving rise to a mesenchymal phenotype (fibroblast/miofibroblasts) has been well recognized as a...
7.
Skoulidis F, Goldberg M, Greenawalt D, Hellmann M, Awad M, Gainor J, et al.
Cancer Discov
. 2018 May;
8(7):822-835.
PMID: 29773717
is the most common oncogenic driver in lung adenocarcinoma (LUAC). We previously reported that (KL) or (KP) comutations define distinct subgroups of -mutant LUAC. Here, we examine the efficacy of...
8.
Galan-Cobo A, Ramirez-Lorca R, Echevarria M
Channels (Austin)
. 2016 Jan;
10(3):185-201.
PMID: 26752515
In addition to the extensive data demonstrating the importance of mammalian AQPs for the movement of water and some small solutes across the cell membrane, there is now a growing...
9.
Galan-Cobo A, Ramirez-Lorca R, Serna A, Echevarria M
PLoS One
. 2015 Sep;
10(9):e0137692.
PMID: 26367709
Abnormal AQP3 overexpression in tumor cells of different origins has been reported and a role for this enhanced AQP3 expression in cell proliferation and tumor processess has been indicated. To...
10.
Galan-Cobo A, Ramirez-Lorca R, Toledo-Aral J, Echevarria M
J Cell Physiol
. 2015 Jun;
231(1):243-56.
PMID: 26081645
Aquaporin-1 (AQP1) has been associated with tumor development. Here, we investigated how AQP1 may affect cell proliferation. The proliferative rate of adult carotid body (CB) cells, known to proliferate under...