Amy Hin Yan Tong
Overview
Explore the profile of Amy Hin Yan Tong including associated specialties, affiliations and a list of published articles.
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Articles
36
Citations
4727
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Recent Articles
1.
Ni Z, Ahmed N, Nabeel-Shah S, Guo X, Pu S, Song J, et al.
Nucleic Acids Res
. 2024 Apr;
52(8):4483-4501.
PMID: 38587191
Messenger RNA precursors (pre-mRNA) generally undergo 3' end processing by cleavage and polyadenylation (CPA), which is specified by a polyadenylation site (PAS) and adjacent RNA sequences and regulated by a...
2.
Amitzi L, Cozma E, Tong A, Chan K, Ross C, ONeil N, et al.
G3 (Bethesda)
. 2024 Mar;
14(5).
PMID: 38478595
DDX11/Chl1R is a conserved DNA helicase with roles in genome maintenance, DNA replication, and chromatid cohesion. Loss of DDX11 in humans leads to the rare cohesinopathy Warsaw breakage syndrome. DDX11...
3.
Varland S, Silva R, Kjosas I, Faustino A, Bogaert A, Billmann M, et al.
Nat Commun
. 2023 Oct;
14(1):6774.
PMID: 37891180
Most eukaryotic proteins are N-terminally acetylated, but the functional impact on a global scale has remained obscure. Using genome-wide CRISPR knockout screens in human cells, we reveal a strong genetic...
4.
Chan K, Farias A, Lee H, Guvenc F, Mero P, Brown K, et al.
Heliyon
. 2023 Jan;
9(1):e12744.
PMID: 36597481
SARS-CoV-2 depends on host cell components for infection and replication. Identification of virus-host dependencies offers an effective way to elucidate mechanisms involved in viral infection and replication. If druggable, host...
5.
Feng Y, Li C, Stewart J, Barbulescu P, Seija Desivo N, Alvarez-Quilon A, et al.
Nature
. 2021 Nov;
600(7888):324-328.
PMID: 34819670
Activation-induced cytidine deaminase (AID) catalyses the deamination of deoxycytidines to deoxyuracils within immunoglobulin genes to induce somatic hypermutation and class-switch recombination. AID-generated deoxyuracils are recognized and processed by subverted base-excision...
6.
Bailey M, Tieu D, Habsid A, Tong A, Chan K, Moffat J, et al.
Life Sci Alliance
. 2021 Aug;
4(11).
PMID: 34462321
, a component of the mitotically essential cohesin complex, is highly mutated in several different tumour types, including glioblastoma and bladder cancer. Whereas cohesin has roles in many cancer-related pathways,...
7.
Lawson K, Sousa C, Zhang X, Kim E, Akthar R, Caumanns J, et al.
Nature
. 2020 Sep;
586(7827):120-126.
PMID: 32968282
The genetic circuits that allow cancer cells to evade destruction by the host immune system remain poorly understood. Here, to identify a phenotypically robust core set of genes and pathways...
8.
Chan K, Tong A, Brown K, Mero P, Moffat J
J Vis Exp
. 2019 Sep;
(151).
PMID: 31545321
Genome editing using the CRISPR-Cas system has vastly advanced the ability to precisely edit the genomes of various organisms. In the context of mammalian cells, this technology represents a novel...
9.
Mair B, Tomic J, Masud S, Tonge P, Weiss A, Usaj M, et al.
Cell Rep
. 2019 Apr;
27(2):599-615.e12.
PMID: 30970261
Human pluripotent stem cells (hPSCs) provide an invaluable tool for modeling diseases and hold promise for regenerative medicine. For understanding pluripotency and lineage differentiation mechanisms, a critical first step involves...
10.
Aregger M, Chandrashekhar M, Tong A, Chan K, Moffat J
Methods Mol Biol
. 2018 Oct;
1869:169-188.
PMID: 30324523
CRISPR-Cas9 technology provides a simple way to introduce targeted mutations into mammalian cells to induce loss-of-function phenotypes. The CRISPR-Cas9 system has now successfully been applied for genetic screens in many...