Kevin R Brown
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Explore the profile of Kevin R Brown including associated specialties, affiliations and a list of published articles.
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61
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4114
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Recent Articles
1.
Mikolajewicz N, Tatari N, Wei J, Savage N, Farias A, Dimitrov V, et al.
Acta Neuropathol
. 2024 Nov;
148(1):74.
PMID: 39592459
Cancer-intrinsic immune evasion mechanisms and pleiotropy are a barrier to cancer immunotherapy. This is apparent in certain highly fatal cancers, including high-grade gliomas and glioblastomas (GBM). In this study, we...
2.
Chokshi C, Vaseem Shaikh M, Brakel B, Rossotti M, Tieu D, Maich W, et al.
Nat Med
. 2024 Aug;
30(10):2936-2946.
PMID: 39095594
Resistance to genotoxic therapies and tumor recurrence are hallmarks of glioblastoma (GBM), an aggressive brain tumor. In this study, we investigated functional drivers of post-treatment recurrent GBM through integrative genomic...
3.
Xiao Y, Lee S, Aguilera-Uribe M, Samson R, Au A, Khanna Y, et al.
Cell Rep
. 2024 Jul;
43(7):114417.
PMID: 38980795
The ability to sense and respond to osmotic fluctuations is critical for the maintenance of cellular integrity. We used gene co-essentiality analysis to identify an unappreciated relationship between TSC22D2, WNK1,...
4.
Chan K, Farias A, Lee H, Guvenc F, Mero P, Brown K, et al.
Heliyon
. 2023 Jan;
9(1):e12744.
PMID: 36597481
SARS-CoV-2 depends on host cell components for infection and replication. Identification of virus-host dependencies offers an effective way to elucidate mechanisms involved in viral infection and replication. If druggable, host...
5.
Gwynne W, Suk Y, Custers S, Mikolajewicz N, Chan J, Zador Z, et al.
Cancer Cell
. 2022 Nov;
40(12):1488-1502.e7.
PMID: 36368321
MYC-driven medulloblastoma (MB) is an aggressive pediatric brain tumor characterized by therapy resistance and disease recurrence. Here, we integrated data from unbiased genetic screening and metabolomic profiling to identify multiple...
6.
Mikolajewicz N, Gacesa R, Aguilera-Uribe M, Brown K, Moffat J, Han H
Commun Biol
. 2022 Oct;
5(1):1142.
PMID: 36307536
Single-cell RNA-sequencing (scRNA-seq) offers functional insight into complex biology, allowing for the interrogation of cellular populations and gene expression programs at single-cell resolution. Here, we introduce scPipeline, a single-cell data...
7.
Qazi M, Salim S, Brown K, Mikolajewicz N, Savage N, Han H, et al.
Cell Rep
. 2022 Sep;
40(13):111420.
PMID: 36170831
Recurrence of solid tumors renders patients vulnerable to advanced, treatment-refractory disease state with mutational and oncogenic landscape distinctive from initial diagnosis. Improving outcomes for recurrent cancers requires a better understanding...
8.
Han H, Best A, Braunschweig U, Mikolajewicz N, Li J, Roth J, et al.
Mol Cell
. 2022 Aug;
82(16):2982-2999.e14.
PMID: 35914530
Alternative splicing (AS) is a critical regulatory layer; yet, factors controlling functionally coordinated splicing programs during developmental transitions are poorly understood. Here, we employ a screening strategy to identify factors...
9.
Chang C, Jen J, Jiang S, Sayad A, Mer A, Brown K, et al.
Cancer Discov
. 2021 Dec;
12(4):1022-1045.
PMID: 34911733
Significance: DTPs are implicated in resistance to anticancer therapies, but their ontogeny and vulnerabilities remain unclear. We find that HER2 TKI-DTPs emerge from stochastically arising primed cells ("pre-DTPs") that engage...
10.
Tang Y, Qazi M, Brown K, Mikolajewicz N, Moffat J, Singh S, et al.
Neurooncol Adv
. 2021 Nov;
3(1):vdab144.
PMID: 34765972
Background: Glioblastoma (GBM), the most common and aggressive primary brain tumour in adults, has been classified into three subtypes: classical, mesenchymal, and proneural. While the original classification relied on an...