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Amy E Pasquinelli

Explore the profile of Amy E Pasquinelli including associated specialties, affiliations and a list of published articles. Areas
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Articles 64
Citations 4055
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Recent Articles
1.
Schiksnis E, Nicastro I, Pasquinelli A
Nucleic Acids Res . 2024 Nov; 52(22):13896-13913. PMID: 39558169
Organismal aging is marked by decline in cellular function and anatomy, ultimately resulting in death. To inform our understanding of the mechanisms underlying this degeneration, we performed standard RNA sequencing...
2.
Schiksnis E, Nicastro I, Pasquinelli A
bioRxiv . 2024 Jul; PMID: 38948813
Organismal aging is marked by decline in cellular function and anatomy, ultimately resulting in death. To inform our understanding of the mechanisms underlying this degeneration, we performed standard RNA sequencing...
3.
Chipman L, Luc S, Nicastro I, Hulahan J, Dann D, Bodas D, et al.
PLoS Genet . 2023 Nov; 19(11):e1011055. PMID: 38011256
MicroRNAs (miRNAs) regulate gene expression by base-pairing to target sequences in messenger RNAs (mRNAs) and recruiting factors that induce translational repression and mRNA decay. In animals, nucleotides 2-8 at the...
4.
Elder C, Pasquinelli A
Front Aging . 2022 Jul; 3:871226. PMID: 35821862
The use of as a model organism in aging research has been integral to our understanding of genes and pathways involved in this process. Several well-conserved signaling pathways that respond...
5.
Nicholson-Shaw A, Kofman E, Yeo G, Pasquinelli A
Nucleic Acids Res . 2022 Apr; 50(8):4685-4702. PMID: 35438785
The poly(A)-tail appended to the 3'-end of most eukaryotic transcripts plays a key role in their stability, nuclear transport, and translation. These roles are largely mediated by Poly(A) Binding Proteins...
6.
Garrigues J, Pasquinelli A
G3 (Bethesda) . 2022 Jan; 12(3). PMID: 35088854
Transposable elements are powerful agents of evolution that can diversify transcriptional programs by distributing transcription factor DNA-binding sites throughout genomes. To investigate the extent that transposable elements provide transcription factor-binding...
7.
Pagliuso D, Bodas D, Pasquinelli A
PLoS Genet . 2021 Aug; 17(8):e1009734. PMID: 34351906
The heat shock response (HSR) is a highly conserved cellular process that promotes survival during stress. A hallmark of the HSR is the rapid induction of heat shock proteins (HSPs),...
8.
Garrigues J, Tsu B, Daugherty M, Pasquinelli A
Elife . 2019 Dec; 8. PMID: 31825311
Heat Shock Factor 1 (HSF-1) is a key regulator of the heat shock response (HSR). Upon heat shock, HSF-1 binds well-conserved motifs, called Heat Shock Elements (HSEs), and drives expression...
9.
Winkenbach L, Doser R, Reed K, Pasquinelli A, Phillips C, Claycomb J
RNA Biol . 2019 Aug; 16(11):1526-1530. PMID: 31397621
Worm biologists from the United States, Canada, and the United Kingdom gathered at the Colorado State University Todos Santos Center in Baja California Sur, Mexico, April 3-5, 2019 for the...
10.
Schreiner W, Pagliuso D, Garrigues J, Chen J, Aalto A, Pasquinelli A
Nucleic Acids Res . 2019 Aug; 47(18):9829-9841. PMID: 31396626
Elevated temperatures activate a heat shock response (HSR) to protect cells from the pathological effects of protein mis-folding, cellular mis-organization, organelle dysfunction and altered membrane fluidity. This response includes activation...