Amiya Sinha Hikim
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Explore the profile of Amiya Sinha Hikim including associated specialties, affiliations and a list of published articles.
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10
Citations
334
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Recent Articles
1.
Jimenez T, Friedman T, Vadgama J, Singh V, Tucker A, Collazo J, et al.
Mediators Inflamm
. 2021 Jan;
2020:5239419.
PMID: 33414685
Breast cancer results from a complex interplay of genetics and environment that alters immune and inflammatory systems to promote tumorigenesis. Obesity and cigarette smoking are well-known risk factors associated breast...
2.
Hoa N, Tsui S, Afifiyan N, Hikim A, Li B, Douglas R, et al.
PLoS One
. 2012 Apr;
7(4):e34173.
PMID: 22506015
Insulin-like growth factor-1 receptor (IGF-1R) comprises two subunits, including a ligand binding domain on extra- cellular IGF-1Rα and a tyrosine phosphorylation site located on IGF-1Rβ. IGF-1R is over-expressed by orbital...
3.
Zhu H, Cui Y, Xie J, Chen L, Chen X, Guo X, et al.
Proteomics
. 2010 Sep;
10(19):3480-93.
PMID: 20815088
Mild testicular heating safely and reversibly suppresses spermatogenesis. In this study, we attempted to clarify the underlying molecular mechanism(s) involved in heat-induced spermatogenesis suppression in human testis. We conducted global...
4.
Liu P, Erkkila K, Lue Y, Jentsch J, Schwarcz M, Abuyounes D, et al.
Am J Physiol Endocrinol Metab
. 2010 Jun;
299(3):E446-55.
PMID: 20570823
XXY men (Klinefelter syndrome) are testosterone deficient, socially isolated, exhibit impaired gender identity, and may experience more homosexual behaviors. Here, we characterize social behaviors in a validated XXY mouse model...
5.
Lue Y, Swerdloff R, Liu Q, Mehta H, Hikim A, Lee K, et al.
Endocrinology
. 2009 Dec;
151(1):350-7.
PMID: 19952275
Modulating germ cell death and survival have significant therapeutic potential for male infertility and contraception. We have shown previously that IGF binding protein 3 (IGFBP3) gene expression is up-regulated in...
6.
Jia Y, Lee K, Swerdloff R, Hwang D, Cobb L, Hikim A, et al.
J Biol Chem
. 2009 Nov;
285(3):1726-32.
PMID: 19887447
Germ cell apoptosis is crucial for spermatogenesis and can be triggered by various stimuli, including intratesticular hormone deprivation. This study proposes a role for insulin-like growth factor binding protein-3 (IGFBP-3)...
7.
Tsui S, Naik V, Hoa N, Hwang C, Afifiyan N, Hikim A, et al.
J Immunol
. 2008 Sep;
181(6):4397-405.
PMID: 18768899
Thyroid-stimulating hormone receptor (TSHR) plays a central role in regulating thyroid function and is targeted by IgGs in Graves' disease (GD-IgG). Whether TSHR is involved in the pathogenesis of thyroid-associated...
8.
Cui Y, Zhu H, Zhu Y, Guo X, Huo R, Wang X, et al.
J Proteome Res
. 2008 Aug;
7(9):3984-93.
PMID: 18702538
Treatment with injectable testosterone undecanoate (TU) alone or in combination with oral levonorgestrel (LNG) resulted in marked decreases in sperm concentrations. In this study, we used proteomic analyses to examine...
9.
Wang C, Cui Y, Wang X, Jia Y, Hikim A, Lue Y, et al.
J Clin Endocrinol Metab
. 2007 May;
92(8):3292-304.
PMID: 17504903
Context: In rodents and monkeys, a combination of hormonal and physical agents accelerates germ cell death. Objective: A "proof of concept" study was performed to investigate whether addition of heat...
10.
Lue Y, Erkkila K, Liu P, Ma K, Wang C, Hikim A, et al.
Am J Pathol
. 2007 Feb;
170(3):899-908.
PMID: 17322375
To assess adult stem cell differentiation in the testis, we injected bone marrow cells from adult green fluorescent protein (GFP) transgenic mice into the seminiferous tubules and the testicular interstitium...