Amir Vajdi
Overview
Explore the profile of Amir Vajdi including associated specialties, affiliations and a list of published articles.
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Articles
12
Citations
530
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0
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Recent Articles
1.
Flechon A, Morales-Barrera R, Powles T, Alva A, Ozguroglu M, Csoszi T, et al.
Clin Cancer Res
. 2024 Oct;
30(23):5353-5364.
PMID: 39475359
Purpose: The three-arm, phase III KEYNOTE-361 study did not meet its dual primary endpoints of progression-free survival (PFS) or overall survival (OS) with first-line pembrolizumab plus chemotherapy versus chemotherapy in...
2.
Szabo P, Vajdi A, Kumar N, Tolstorukov M, Chen B, Edwards R, et al.
Sci Rep
. 2023 Feb;
13(1):3051.
PMID: 36810872
Epithelial-to-mesenchymal transition (EMT) is associated with tumor initiation, metastasis, and drug resistance. However, the mechanisms underlying these associations are largely unknown. We studied several tumor types to identify the source...
3.
Noyes C, Kitajima S, Li F, Suita Y, Miriyala S, Isaac S, et al.
Commun Biol
. 2023 Jan;
6(1):65.
PMID: 36653474
Human cancers often re-express germline factors, yet their mechanistic role in oncogenesis and cancer progression remains unknown. Here we demonstrate that DEAD-box helicase 4 (DDX4), a germline factor and RNA...
4.
Yoshida R, Saigi M, Tani T, Springer B, Shibata H, Kitajima S, et al.
Cancer Res
. 2022 Sep;
82(21):4079-4092.
PMID: 36066413
Significance: MET amplification upregulates CD73 to suppress tumor cell STING induction and T-cell responsiveness in TKI-resistant, EGFR-mutated lung cancer, identifying a strategy to enhance immunogenicity and improve treatment.
5.
Chen H, Durmaz Y, Li Y, Sabet A, Vajdi A, Denize T, et al.
Nat Commun
. 2022 Aug;
13(1):4998.
PMID: 36008402
Some small cell lung cancers (SCLCs) are highly sensitive to inhibitors of the histone demethylase LSD1. LSD1 inhibitors are thought to induce their anti-proliferative effects by blocking neuroendocrine differentiation, but...
6.
Primo Jr V, Rezvani Y, Farrell A, Murphy C, Lou J, Vajdi A, et al.
mSystems
. 2021 Dec;
6(6):e0119621.
PMID: 34874774
Evolve and resequencing (E&R) was applied to lab adaptation of Toxoplasma gondii for over 1,500 generations with the goal of mapping host-independent virulence traits. Phenotypic assessments of steps across the...
7.
Hong D, Knelson E, Li Y, Durmaz Y, Gao W, Walton E, et al.
Cancer Res
. 2021 Nov;
82(2):248-263.
PMID: 34810201
Neuroendocrine to nonneuroendocrine plasticity supports small cell lung cancer (SCLC) tumorigenesis and promotes immunogenicity. Approximately 20% to 25% of SCLCs harbor loss-of-function (LOF) mutations. Previous studies demonstrated that NOTCH functions...
8.
Ricciuti B, Arbour K, Lin J, Vajdi A, Vokes N, Hong L, et al.
J Thorac Oncol
. 2021 Nov;
17(3):399-410.
PMID: 34740862
Introduction: STK11 and KEAP1 mutations (STK11 mutant [STK11] and KEAP1) are among the most often mutated genes in lung adenocarcinoma (LUAD). Although STK11 has been associated with resistance to programmed...
9.
Mahadevan N, Knelson E, Wolff J, Vajdi A, Saigi M, Campisi M, et al.
Cancer Discov
. 2021 Mar;
11(8):1952-1969.
PMID: 33707236
Small cell lung carcinoma (SCLC) is highly mutated, yet durable response to immune checkpoint blockade (ICB) is rare. SCLC also exhibits cellular plasticity, which could influence its immunobiology. Here we...
10.
Sehgal K, Portell A, Ivanova E, Lizotte P, Mahadevan N, Greene J, et al.
J Clin Invest
. 2020 Nov;
131(2).
PMID: 33151910
Resistance to oncogene-targeted therapies involves discrete drug-tolerant persister cells, originally discovered through in vitro assays. Whether a similar phenomenon limits efficacy of programmed cell death 1 (PD-1) blockade is poorly...