Amir Rattner
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Explore the profile of Amir Rattner including associated specialties, affiliations and a list of published articles.
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31
Citations
1612
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Recent Articles
11.
Sabbagh M, Heng J, Luo C, Castanon R, Nery J, Rattner A, et al.
Elife
. 2018 Sep;
7.
PMID: 30188322
Vascular endothelial cell (EC) function depends on appropriate organ-specific molecular and cellular specializations. To explore genomic mechanisms that control this specialization, we have analyzed and compared the transcriptome, accessible chromatin,...
12.
Wang Y, Williams J, Rattner A, Wu S, Bassuk A, Goffinet A, et al.
Dev Biol
. 2016 Sep;
419(2):298-310.
PMID: 27612405
The dorsal surface of the mouse tongue is covered by ~7000 papillae, asymmetric epithelial protrusions that are precisely oriented to create a stereotyped macroscopic pattern. Within the context of this...
13.
Wang Y, Chang H, Rattner A, Nathans J
Curr Top Dev Biol
. 2016 Mar;
117:113-39.
PMID: 26969975
Frizzled proteins are the principal receptors for the Wnt family of ligands. They mediate canonical Wnt signaling together with Lrp5 and Lrp6 coreceptors. In conjunction with Celsr, Vangl, and a...
14.
Rattner A, Wang Y, Zhou Y, Williams J, Nathans J
Invest Ophthalmol Vis Sci
. 2014 Nov;
55(12):8614-25.
PMID: 25414188
Purpose: To define the role of hypoxia and vascular endothelial growth factor (VEGF) in modifying the pattern, density, and permeability of the retinal vasculature in mouse models in which Norrin/Frizzled4...
15.
Zhou Y, Wang Y, Tischfield M, Williams J, Smallwood P, Rattner A, et al.
J Clin Invest
. 2014 Aug;
124(9):3825-46.
PMID: 25083995
Canonical WNT signaling is required for proper vascularization of the CNS during embryonic development. Here, we used mice with targeted mutations in genes encoding canonical WNT pathway members to evaluate...
16.
Wu H, Luo J, Yu H, Rattner A, Mo A, Wang Y, et al.
Neuron
. 2014 Jan;
81(1):103-19.
PMID: 24411735
Female eutherian mammals use X chromosome inactivation (XCI) to epigenetically regulate gene expression from ∼4% of the genome. To quantitatively map the topography of XCI for defined cell types at...
17.
Rattner A, Yu H, Williams J, Smallwood P, Nathans J
Proc Natl Acad Sci U S A
. 2013 Sep;
110(40):E3830-9.
PMID: 24043815
Endothelin signaling is required for neural crest migration and homeostatic regulation of blood pressure. Here, we report that constitutive overexpression of Endothelin-2 (Edn2) in the mouse retina perturbs vascular development...
18.
Chang I, Bramall A, Baynash A, Rattner A, Rakheja D, Post M, et al.
J Clin Invest
. 2013 May;
123(6):2643-53.
PMID: 23676500
To explore the physiological functions of endothelin-2 (ET-2), we generated gene-targeted mouse models. Global Et2 knockout mice exhibited severe growth retardation and juvenile lethality. Despite normal milk intake, they suffered...
19.
Huang L, Rattner A, Liu H, Nathans J
Elife
. 2013 Mar;
2:e00638.
PMID: 23538852
The use of the least squares method to calculate the best-fitting line through a two-dimensional scatter plot typically requires the user to assume that one of the variables depends on...
20.
Wang Y, Rattner A, Zhou Y, Williams J, Smallwood P, Nathans J
Cell
. 2012 Dec;
151(6):1332-44.
PMID: 23217714
Norrin/Frizzled4 (Fz4) signaling activates the canonical Wnt pathway to control retinal vascular development. Using genetically engineered mice, we show that precocious Norrin production leads to premature retinal vascular invasion and...