Amin Rostami-Hodjegan
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Explore the profile of Amin Rostami-Hodjegan including associated specialties, affiliations and a list of published articles.
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253
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5467
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Recent Articles
1.
Vasilogianni A, Achour B, Al-Majdoub Z, Peters S, Barber J, Rostami-Hodjegan A
Expert Opin Drug Metab Toxicol
. 2025 Mar;
PMID: 40042382
Introduction: Clinical trials in oncology initially recruit heterogeneous populations, without catering for all types of variability. The target cohort is often not representative, leading to variability in pharmacokinetics (PK). To...
2.
Alrubia S, Achour B, Al-Majdoub Z, Rostami-Hodjegan A, Barber J
Br J Clin Pharmacol
. 2025 Mar;
PMID: 40040248
Aims: The aim of study was to generate quantitative data on the abundance of drug-metabolizing enzymes and transporters (DMETs) in inflamed and non-inflamed Crohn's disease (CD) ileum and colon, for...
3.
Tan S, Wu H, Rostami-Hodjegan A, Scotcher D, Galetin A
CPT Pharmacometrics Syst Pharmacol
. 2025 Mar;
PMID: 40033714
Evaluation of transporter-mediated drug-drug interactions (DDI) with endogenous biomarkers, coupled with physiologically-based pharmacokinetic modeling (PBPK) is envisioned to replace or reduce dedicated DDI clinical trials with clinical probe substrates. The...
4.
Al-Majdoub Z, Freriksen J, Colbers A, van den Heuvel J, Koenderink J, Abduljalil K, et al.
Drug Metab Dispos
. 2025 Jan;
53(1):100007.
PMID: 39884812
The placenta acts as a barrier, excluding noxious substances while actively transferring nutrients to the fetus, mediated by various transporters. This study quantified the expression of key placental transporters in...
5.
Al-Majdoub Z, Cheong J, Mizuno K, Hogan J, De Bruyn T, Kanta A, et al.
Eur J Pharm Sci
. 2025 Jan;
107022.
PMID: 39826620
Access of drugs to the central nervous system is limited by the blood-brain barrier, and this in turn affects drug efficacy/toxicity. To date, most drug discovery optimization paradigms have relied...
6.
Tiryannik I, Heikkinen A, Gardner I, Onasanwo A, Jamei M, Polasek T, et al.
Clin Pharmacokinet
. 2024 Dec;
64(1):155-170.
PMID: 39656410
Background: Predicting metabolic drug-drug interactions (DDIs) via cytochrome P450 enzymes (CYP) is essential in drug development, but controversy has reemerged recently about whether in vitro-in vivo extrapolation (IVIVE) using static...
7.
Heimbach T, Musuamba Tshinanu F, Raines K, Borges L, Kijima S, Malamatari M, et al.
Mol Pharm
. 2024 Sep;
21(11):5353-5372.
PMID: 39348508
The proceedings from the 30th August 2023 (Day 2) of the workshop "Physiologically Based Biopharmaceutics Models (PBBM) Best Practices for Drug Product Quality: Regulatory and Industry Perspectives" are provided herein....
8.
Sychterz C, Shen H, Zhang Y, Sinz M, Rostami-Hodjegan A, Schmidt B, et al.
CPT Pharmacometrics Syst Pharmacol
. 2024 Sep;
13(11):1856-1869.
PMID: 39292199
Breastfeeding is the most complete nutritional method of feeding infants, but several impediments affect the decision to breastfeed, including questions of drug safety for medications needed during lactation. Despite recent...
9.
Tan S, Tillmann A, Murby S, Rostami-Hodjegan A, Scotcher D, Galetin A
Mol Pharm
. 2024 Aug;
21(9):4603-4617.
PMID: 39166754
Modulation of the transport-mediated active uptake by human serum albumin (HSA) for highly protein-bound substrates has been reported and improved the -to- extrapolation (IVIVE) of hepatic clearance. However, evidence for...
10.
Curry L, Alrubia S, Bois F, Clayton R, El-Khateeb E, Johnson T, et al.
CPT Pharmacometrics Syst Pharmacol
. 2024 Jul;
13(9):1429-1447.
PMID: 39030888
The Simcyp Simulator is a software platform widely used in the pharmaceutical industry to conduct stochastic physiologically-based pharmacokinetic (PBPK) modeling. This approach has the advantage of combining routinely generated in ...