Trevor N Johnson
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Explore the profile of Trevor N Johnson including associated specialties, affiliations and a list of published articles.
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73
Citations
1496
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Recent Articles
1.
Abd-Elsayed A, Johnson T, Ruprecht K, Argall T, Henjum L, Fiala K
Pain Ther
. 2025 Mar;
PMID: 40063221
Introduction: Worldwide, 23% of adults suffer from chronic lower back pain, which is defined as pain persisting for more than 3-6 months [Merskey in Can J Psychiatry 34:329-336, 1989]. The...
2.
Date K, Baster K, Caunt S, Cohen J, Debono M, Fearnside J, et al.
BMJ Open
. 2025 Jan;
14(12):e094830.
PMID: 39806610
Introduction: Cortisol is an essential stress hormone and failure of its production, known as adrenal insufficiency (AI), is associated with significant mortality due to adrenal crisis. The Short Synacthen Test...
3.
Curry L, Alrubia S, Bois F, Clayton R, El-Khateeb E, Johnson T, et al.
CPT Pharmacometrics Syst Pharmacol
. 2024 Jul;
13(9):1429-1447.
PMID: 39030888
The Simcyp Simulator is a software platform widely used in the pharmaceutical industry to conduct stochastic physiologically-based pharmacokinetic (PBPK) modeling. This approach has the advantage of combining routinely generated in ...
4.
Johnson T, Batchelor H, Goelen J, Horniblow R, Dinh J
CPT Pharmacometrics Syst Pharmacol
. 2024 Jun;
13(9):1570-1581.
PMID: 38923249
Pediatric physiologically-based modeling in drug development has grown in the past decade and optimizing the underlying systems parameters is important in relation to overall performance. In this study, variation of...
5.
van Hoogdalem M, Tanaka R, Johnson T, Vinks A, Mizuno T
Drug Metab Dispos
. 2024 May;
52(8):785-796.
PMID: 38769016
Sublingual buprenorphine is used for opioid use disorder and neonatal opioid withdrawal syndrome. The study aimed to develop a full physiologically based pharmacokinetic (PBPK) model that can adequately describe dose-...
6.
Codaccioni M, Southall R, Dinh J, Johnson T
J Clin Pharmacol
. 2024 May;
64(9):1083-1094.
PMID: 38696325
The rapid growth in the use of pediatric physiologically based pharmacokinetic (PBPK) models, particularly for regulatory applications, has focused emphasis on model verification and ensuring system parameters are robust, including...
7.
van Hoogdalem M, Tanaka R, Abduljalil K, Johnson T, Wexelblatt S, Akinbi H, et al.
Pharmaceutics
. 2024 Mar;
16(3).
PMID: 38543269
Buprenorphine readily crosses the placenta, and with greater prenatal exposure, neonatal opioid withdrawal syndrome (NOWS) likely grows more severe. Current dosing strategies can be further improved by tailoring doses to...
8.
Dinh J, Johnson T, Grimstein M, Lewis T
Pharmaceutics
. 2023 Nov;
15(11).
PMID: 38004559
Physiologically based pharmacokinetic (PBPK) modeling is an approach to predicting drug pharmacokinetics, using knowledge of the human physiology involved and drug physiochemical properties. This approach is useful when predicting drug...
9.
Goelen J, Farrell G, McGeehan J, Titman C, Rattray N, Johnson T, et al.
Eur J Pharm Biopharm
. 2023 Aug;
191:68-77.
PMID: 37625656
Characterising the small intestine absorptive membrane is essential to enable prediction of the systemic exposure of oral formulations. In particular, the ontogeny of key intestinal Drug Metabolising Enzymes and Transporter...
10.
Small B, Hatley O, Jamei M, Gardner I, Johnson T
Clin Pharmacol Ther
. 2023 Aug;
114(6):1264-1273.
PMID: 37620290
Patho-physiological changes in liver cirrhosis create portacaval shunts that allow blood flow to bypass the hepatic portal vein into the systemic circulation affecting drug pharmacokinetics (PKs). The objectives of this...