David Frith
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Explore the profile of David Frith including associated specialties, affiliations and a list of published articles.
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24
Citations
939
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Recent Articles
1.
OSullivan P, Aidarova A, Afonina I, Manils J, Thurston T, Instrell R, et al.
Biochem J
. 2024 Aug;
481(18):1143-1171.
PMID: 39145956
Rare mutations in CARD14 promote psoriasis by inducing CARD14-BCL10-MALT1 complexes that activate NF-κB and MAP kinases. Here, the downstream signalling mechanism of the highly penetrant CARD14E138A alteration is described. In...
2.
Investigation and Management of an Outbreak of Lead Intoxication in an Extensively Managed Beef Herd
Scrivens M, Frith D, Wood B, Burren B, Doust A, McGowan M
Animals (Basel)
. 2023 Jan;
13(1).
PMID: 36611782
Fifteen hundred 12−15-month-old tropically adapted heifers inadvertently grazed a paddock which had a refuse dump in it containing burnt out vehicle batteries. The cattle grazed this paddock for approximately seven...
3.
Mercer T, Ohashi Y, Boeing S, Jefferies H, De Tito S, Flynn H, et al.
EMBO J
. 2021 Jun;
40(14):e105985.
PMID: 34121209
Autophagy is a process through which intracellular cargoes are catabolised inside lysosomes. It involves the formation of autophagosomes initiated by the serine/threonine kinase ULK and class III PI3 kinase VPS34...
4.
Young J, Broncel M, Teague H, Russell M, McGovern O, Renshaw M, et al.
mSphere
. 2020 Sep;
5(5).
PMID: 32907954
The intracellular parasite resides within a membrane-bound parasitophorous vacuole (PV) and secretes an array of proteins to establish this replicative niche. It has been shown previously that secretes kinases and...
5.
CD9 identifies pancreatic cancer stem cells and modulates glutamine metabolism to fuel tumour growth
Wang V, Ferreira R, Almagro J, Evan T, Legrave N, Zaw Thin M, et al.
Nat Cell Biol
. 2019 Nov;
21(11):1425-1435.
PMID: 31685994
Pancreatic ductal adenocarcinoma (PDAC) shows great cellular heterogeneity, with pronounced epithelial and mesenchymal cancer cell populations. However, the cellular hierarchy underlying PDAC cell diversity is unknown. Here we identify the...
6.
Fulford A, Holder M, Frith D, Snijders A, Tapon N, Ribeiro P
Elife
. 2019 Oct;
8.
PMID: 31567070
Hippo signalling integrates diverse stimuli related to epithelial architecture to regulate tissue growth and cell fate decisions. The Hippo kinase cascade represses the growth-promoting transcription co-activator Yorkie. The FERM protein...
7.
Judith D, Jefferies H, Boeing S, Frith D, Snijders A, Tooze S
J Cell Biol
. 2019 Mar;
218(5):1634-1652.
PMID: 30917996
ATG9A is a multispanning membrane protein essential for autophagy. Normally resident in Golgi membranes and endosomes, during amino acid starvation, ATG9A traffics to sites of autophagosome formation. ATG9A is not...
8.
Wu A, Patel H, Chia M, Moretto F, Frith D, Snijders A, et al.
Mol Cell
. 2018 Dec;
72(6):942-954.e7.
PMID: 30576656
Many active eukaryotic gene promoters exhibit divergent noncoding transcription, but the mechanisms restricting expression of these transcripts are not well understood. Here, we demonstrate how a sequence-specific transcription factor represses...
9.
Elbediwy A, Vanyai H, Diaz-de-la-Loza M, Frith D, Snijders A, Thompson B
J Cell Sci
. 2018 Nov;
131(22).
PMID: 30404826
Human cells can sense mechanical stress acting upon integrin adhesions and respond by sending the YAP (also known as YAP1) and TAZ (also known as WWTR1) transcriptional co-activators to the...
10.
Gordon O, Henry C, Srinivasan N, Ahrens S, Franz A, Deddouche S, et al.
Elife
. 2018 Sep;
7.
PMID: 30260317
Damage-associated molecular patterns (DAMPs) are molecules exposed or released by dead cells that trigger or modulate immunity and tissue repair. In vertebrates, the cytoskeletal component F-actin is a DAMP specifically...