Amanda M Travis
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Explore the profile of Amanda M Travis including associated specialties, affiliations and a list of published articles.
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9
Citations
139
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Recent Articles
1.
Truong H, Cruz-Colon K, Martinez-Marquez J, Willer J, Travis A, Biswas S, et al.
Nat Commun
. 2023 Sep;
14(1):5671.
PMID: 37704658
The primary cilium is a signaling organelle with a unique membrane composition maintained by a diffusional barrier residing at the transition zone. Many transition zone proteins, such as the tectonic...
2.
Travis A, Pearring J
Adv Exp Med Biol
. 2023 Jul;
1415:283-288.
PMID: 37440046
Photoreceptors are highly polarized sensory neurons. Precise localization of signaling molecules within the ciliary outer segment is critical for photoreceptor function and viability. The small GTPase Arl3 plays a particularly...
3.
Travis A, Manocha S, Willer J, Wessler T, Skiba N, Pearring J
Elife
. 2023 Jan;
12.
PMID: 36598133
The small GTPase Arl3 is important for the enrichment of lipidated proteins to primary cilia, including the outer segment of photoreceptors. Human mutations in the small GTPase Arl3 cause both...
4.
Wang L, Klingeborn M, Travis A, Hao Y, Arshavsky V, Gospe 3rd S
Sci Rep
. 2020 Oct;
10(1):16326.
PMID: 33004958
Optic atrophy resulting from retinal ganglion cell (RGC) degeneration is a prominent ocular manifestation of mitochondrial dysfunction. Although transgenic mice lacking the mitochondrial complex I accessory subunit NDUFS4 develop early-onset...
5.
Gospe 3rd S, Travis A, Kolesnikov A, Klingeborn M, Wang L, Kefalov V, et al.
J Biol Chem
. 2019 Jun;
294(33):12432-12443.
PMID: 31248988
Mitochondrial dysfunction is an important cause of heritable vision loss. Mutations affecting mitochondrial bioenergetics may lead to isolated vision loss or life-threatening systemic disease, depending on a mutation's severity. Primary...
6.
Spencer W, Ding J, Lewis T, Yu C, Phan S, Pearring J, et al.
Proc Natl Acad Sci U S A
. 2019 Jun;
116(26):13087-13096.
PMID: 31189593
Progressive rod-cone degeneration (PRCD) is a small protein residing in the light-sensitive disc membranes of the photoreceptor outer segment. Until now, the function of PRCD has remained enigmatic despite multiple...
7.
Lobanova E, Finkelstein S, Li J, Travis A, Hao Y, Klingeborn M, et al.
Nat Commun
. 2018 May;
9(1):1738.
PMID: 29712894
Inherited retinal degenerations, affecting more than 2 million people worldwide, are caused by mutations in over 200 genes. This suggests that the most efficient therapeutic strategies would be mutation independent,...
8.
Travis A, Heflin S, Hirano A, Brecha N, Arshavsky V
J Neurosci
. 2017 Dec;
38(3):723-732.
PMID: 29217689
The vertebrate retina has the remarkable ability to support visual function under conditions of limited illumination, including the processing of signals evoked by single photons. Dim-light vision is regulated by...
9.
Kosloff M, Travis A, Bosch D, Siderovski D, Arshavsky V
Nat Struct Mol Biol
. 2011 Jun;
18(7):846-53.
PMID: 21685921
The diverse Regulator of G protein Signaling (RGS) family sets the timing of G protein signaling. To understand how the structure of RGS proteins determines their common ability to inactivate...