Edwin D Hawkins
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Explore the profile of Edwin D Hawkins including associated specialties, affiliations and a list of published articles.
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59
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2139
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Recent Articles
1.
Yip R, Hawkins E, Bowden R, Rogers K
Semin Cell Dev Biol
. 2025 Jan;
167:10-21.
PMID: 39889539
The tissue microenvironment refers to a localised tissue area where a complex combination of cells, structural components, and signalling molecules work together to support specific biological activities. A prime example...
2.
MLKL deficiency elevates testosterone production in male mice independently of necroptotic functions
Chiou S, Cawthorne W, Soerianto T, Hofferek V, Patel K, Garnish S, et al.
Cell Death Dis
. 2024 Nov;
15(11):851.
PMID: 39572538
Mixed lineage kinase domain-like (MLKL) is a pseudokinase, best known for its role as the terminal effector of the necroptotic cell death pathway. MLKL-mediated necroptosis has long been linked to...
3.
Tye H, Conos S, Djajawi T, Gottschalk T, Abdoulkader N, Kong I, et al.
Life Sci Alliance
. 2024 Nov;
8(1).
PMID: 39532538
Cell death frequently occurs in the pathogenesis of obesity and metabolic dysfunction-associated fatty liver disease (MAFLD). However, the exact contribution of core cell death machinery to disease manifestations remains ill-defined....
4.
Atkin-Smith G, Santavanond J, Light A, Rimes J, Samson A, Er J, et al.
Nat Commun
. 2024 Oct;
15(1):8802.
PMID: 39438460
Endothelial cells are integral components of all vasculature within complex organisms. As they line the blood vessel wall, endothelial cells are constantly exposed to a variety of molecular factors and...
5.
Todorovski I, Tsang M, Feran B, Fan Z, Gadipally S, Yoannidis D, et al.
NAR Cancer
. 2024 Oct;
6(4):zcae039.
PMID: 39372038
Therapeutic targeting of dysregulated transcription has emerged as a promising strategy for the treatment of cancers, such as leukaemias. The therapeutic response to small molecule inhibitors of Bromodomain-Containing Proteins (BRD),...
6.
Lieschke E, Thomas A, Kueh A, Atkin-Smith G, Baldoni P, La Marca J, et al.
EMBO J
. 2024 Aug;
43(19):4406-4436.
PMID: 39160273
Investigating how transcription factors control complex cellular processes requires tools that enable responses to be visualised at the single-cell level and their cell fate to be followed over time. For...
7.
Chiou S, Al-Ani A, Pan Y, Patel K, Kong I, Whitehead L, et al.
EMBO Mol Med
. 2024 May;
16(7):1717-1749.
PMID: 38750308
Necroptosis is a lytic form of regulated cell death reported to contribute to inflammatory diseases of the gut, skin and lung, as well as ischemic-reperfusion injuries of the kidney, heart...
8.
Speir M, Tye H, Gottschalk T, Simpson D, Djajawi T, Deo P, et al.
EMBO Rep
. 2023 Oct;
24(11):e56865.
PMID: 37846472
Programmed cell death pathways play an important role in innate immune responses to infection. Activation of intrinsic apoptosis promotes infected cell clearance; however, comparatively little is known about how this...
9.
Trezise S, Kong I, Hawkins E, Herold M, Willis S, Nutt S
Front Immunol
. 2023 Mar;
14:1089243.
PMID: 36860866
Background: Humoral immunity depends on the differentiation of B cells into antibody secreting cells (ASCs). Excess or inappropriate ASC differentiation can lead to antibody-mediated autoimmune diseases, while impaired differentiation results...
10.
Cheon H, Kan A, Prevedello G, Oostindie S, Dovedi S, Hawkins E, et al.
Front Bioinform
. 2022 Oct;
1:723337.
PMID: 36303793
Lymphocytes are the central actors in adaptive immune responses. When challenged with antigen, a small number of B and T cells have a cognate receptor capable of recognising and responding...